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Article

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Published version

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2015-06-01

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cc by (c) Velasco, Roser; Bruna, Jordi, 2015
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/126095

Taxane-induced Peripheral Neurotoxicity

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https://doi.org/10.3390/toxics3020152

Abstract

Taxane-derived agents are chemotherapy drugs widely employed in cancer treatment. Among them, paclitaxel and docetaxel are most commonly administered, but newer formulations are being investigated. Taxane antineoplastic activity is mainly based on the ability of the drugs to promote microtubule assembly, leading to mitotic arrest and apoptosis in cancer cells. Peripheral neurotoxicity is the major non-hematological adverse effect of taxane, often manifested as painful neuropathy experienced during treatment, and it is sometimes irreversible. Unfortunately, taxane-induced neurotoxicity is an uncertainty prior to the initiation of treatment. The present review aims to dissect current knowledge on real incidence, underlying pathophysiology, clinical features and predisposing factors related with the development of taxane-induced neuropathy.

Subject

Quimioteràpia, Neurotoxicologia

Subject (English)

Chemotherapy, Neurotoxicology

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citation

VELASCO, Roser and BRUNA, Jordi. Taxane-induced Peripheral Neurotoxicity. Toxics. 2015. Vol. 3, num. 2, pags. 152-169. [consulted: 11 of August of 2026]. Available at: https://hdl.handle.net/2445/126095

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