Carregant...
Tipus de document
Part del llibreVersió
Versió publicadaData de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/128069
An overview on the modulation of the intestinal barrier and immune response by membrane vesicles secreted by the probiotic Escherichia coli Nissle 1917
Títol de la revista
ISSN de la revista
Títol del volum
Resum
Probiotic Escherichia coli Nissle 1917 (EcN) is a good colonizer of the human gut and its efficacy in the inflammatory process undergone in ulcerative colitis has been demonstrated. The probiotic action is mainly through the modulation of intestinal epithelial tight junctions and immune system. Here we review the role of outer membrane vesicles (OMVs) released by this probiotic strain on the modulation of intestinal homeostasis. EcN OMVs enter into host epithelial cells via clathrin-mediated endocytosis and are sorted to lysosomes via endocytic compartments. In cellular models of intestinal barrier, EcN OMVs stimulate the underlying immune system through the intestinal epithelium, triggering immune and defense responses. Thus, the use of probiotic derived OMVs could be a safe probiotic-derived strategy targeting intestinal inflammatory processes.
Descripció
Podeu consultar el llibre complet a: http://hdl.handle.net/2445/128014
Matèries
Matèries (anglès)
Citació
Citació
BADÍA PALACÍN, Josefa, FÁBREGA FERNÁNDEZ, María josé, CAÑAS PACHECO, María alexandra, AGUILERA GIL, Maria laura, GIMÉNEZ CLAUDIO, Rosa, ALVAREZ VILLAGOMEZ, Carina shianya, BALDOMÀ LLAVINÉS, Laura. An overview on the modulation of the intestinal barrier and immune response by membrane vesicles secreted by the probiotic Escherichia coli Nissle 1917. _Recent Advances in Pharmaceutical Sciences VIII_. 2018. Vol. Editors: Diego Muñoz-Torrero, núm. ISBN: 978-81-308-0579-5, pàgs. 19-42. [consulta: 25 de novembre de 2025]. [Disponible a: https://hdl.handle.net/2445/128069]