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2018-01

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cc-by-nc-nd (c) The British Infection Association, 2018
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/131299

Management of MDR-TB in HIV co-infected patients in Eastern Europe: Results from the TB: HIV study

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Recurs relacionat

https://doi.org/10.1016/j.jinf.2017.10.007

Resum

Objectives: Mortality among HIV patients with tuberculosis (TB) remains high in Eastern Europe (EE), but details of TB and HIV management remain scarce. Methods: In this prospective study, we describe the TB treatment regimens of patients with multi-drug resistant (MDR) TB and use of antiretroviral therapy (ART). Results: A total of 105 HIV-positive patients had MDR-TB (including 33 with extensive drug resistance) and 130 pan-susceptible TB. Adequate initial TB treatment was provided for 8% of patients with MDR-TB compared with 80% of those with pan-susceptible TB. By twelve months, an estimated 57.3% (95%CI 41.5-74.1) of MDR-TB patients had started adequate treatment. While 67% received ART, HIV-RNA suppression was demonstrated in only 23%. Conclusions: Our results show that internationally recommended MDR-TB treatment regimens were infrequently used and that ART use and viral suppression was well below the target of 90%, reflecting the challenging patient population and the environment in which health care is provided. Urgent improvement of management of patients with TB/HIV in EE, in particular for those with MDR-TB, is needed and includes widespread access to rapid TB diagnostics, better access to and use of second-line TB drugs, timely ART initiation with viral load monitoring, and integration of TB/HIV care.

Matèries

Infeccions per VIH, Tuberculosi

Matèries (anglès)

HIV infections, Tuberculosis

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Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

EFSEN, Anne Marie W., et al. Management of MDR-TB in HIV co-infected patients in Eastern Europe: Results from the TB: HIV study. Journal of Infection. 2018. Vol. 76, num. 1, pags. 44-54. ISSN 0163-4453. [consulted: 30 of May of 2026]. Available at: https://hdl.handle.net/2445/131299

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