Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/123978
Is Penicillin Plus Gentamicin Synergistic Against Sessile Group B Streptococcal Isolates? An In Vivo Study With An Experimental Model Of Foreign-body Infection
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
The rate of invasive group B Streptococcus (GBS) infections is steadily increasing, particularly in older persons and in adults with diabetes and other comorbidities. This population includes persons with a foreign body (e.g., who have undergone arthroplasty). In a rat tissue cage model, we evaluated the efficacy of adjunctive gentamicin (GEN) administered systemically (5 mg/kg body weight) every 24 h, or locally (12.5 mg/L tissue cage concentration) every 24 or 72 h, in combination with penicillin (PEN) administered systemically (250,000 IU/kg body weight three times per day). The efficacy was evaluated on two different sessile forms of GBS: transition (i.e., in between planktonic and biofilm) and biofilm. After 3 days of treatment, the mean bacterial load reduction of transition-form GBS was greater in all PEN-GEN combination groups than in the PEN monotherapy group (P <= 0.03). The 6-day regimen decreased the bacterial load significantly in comparison to the 3-day regimen, irrespective of growth form and adjunctive GEN (P < 0.01). After 6 days of treatment, the mean reduction in transition-form GBS was greater with PEN plus GEN administered locally every 24 h than with PEN monotherapy (P = 0.03). These results were not confirmed with biofilm GBS. The difference in mean bacterial load reduction between all PEN-GEN and PEN monotherapy groups was <100 CFU/mL. Hence, synergy criteria were not fulfilled. Adjunctive systemic GEN consists of potential side effects and showed poor efficacy in this study. Combining systemic PEN and local GEN has a potential application in the treatment of streptococcal implant-associated infections.
Matèries
Matèries (anglès)
Citació
Citació
RUPPEN, Corinne, MERCIER, Thomas, GRANDGIRARD, Denis, LEIB, Sthephen l., EL HAJ HIDALGO, Cristina, MURILLO RUBIO, Óscar, DECOSTERD, Laurent, SENDI, Parham. Is Penicillin Plus Gentamicin Synergistic Against Sessile Group B Streptococcal Isolates? An In Vivo Study With An Experimental Model Of Foreign-body Infection. _Frontiers In Microbiology_. 2018. Vol. 9, núm. article 919. [consulta: 20 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/123978]