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RuppenC.pdf (3.34 MB)

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2018-05-15

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cc-by (c) Ruppen, Corinne et al., 2018
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/123978

Is Penicillin Plus Gentamicin Synergistic Against Sessile Group B Streptococcal Isolates? An In Vivo Study With An Experimental Model Of Foreign-body Infection

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Recurs relacionat

https://doi.org/10.3389/fmicb.2018.00919

Resum

The rate of invasive group B Streptococcus (GBS) infections is steadily increasing, particularly in older persons and in adults with diabetes and other comorbidities. This population includes persons with a foreign body (e.g., who have undergone arthroplasty). In a rat tissue cage model, we evaluated the efficacy of adjunctive gentamicin (GEN) administered systemically (5 mg/kg body weight) every 24 h, or locally (12.5 mg/L tissue cage concentration) every 24 or 72 h, in combination with penicillin (PEN) administered systemically (250,000 IU/kg body weight three times per day). The efficacy was evaluated on two different sessile forms of GBS: transition (i.e., in between planktonic and biofilm) and biofilm. After 3 days of treatment, the mean bacterial load reduction of transition-form GBS was greater in all PEN-GEN combination groups than in the PEN monotherapy group (P <= 0.03). The 6-day regimen decreased the bacterial load significantly in comparison to the 3-day regimen, irrespective of growth form and adjunctive GEN (P < 0.01). After 6 days of treatment, the mean reduction in transition-form GBS was greater with PEN plus GEN administered locally every 24 h than with PEN monotherapy (P = 0.03). These results were not confirmed with biofilm GBS. The difference in mean bacterial load reduction between all PEN-GEN and PEN monotherapy groups was <100 CFU/mL. Hence, synergy criteria were not fulfilled. Adjunctive systemic GEN consists of potential side effects and showed poor efficacy in this study. Combining systemic PEN and local GEN has a potential application in the treatment of streptococcal implant-associated infections.

Matèries

Estreptococs, Penicil·lina, Biofilms

Matèries (anglès)

Streptococcus, Penicillin, Biofilms

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Col·leccions

Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Clíniques)

Citació

RUPPEN, Corinne, et al. Is Penicillin Plus Gentamicin Synergistic Against Sessile Group B Streptococcal Isolates? An In Vivo Study With An Experimental Model Of Foreign-body Infection. Frontiers In Microbiology. 2018. Vol. 9, num. article 919. [consulted: 14 of August of 2026]. Available at: https://hdl.handle.net/2445/123978

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