Amb motiu del tancament d'estiu, la validació de documents es reprendrà a partir del 28 d'agost de 2026. Disculpeu les molèsties.
Con motivo del cierre de verano, la validación de documentos se reanudará a partir del 28 de agosto de 2026. Disculpad las molestias
Due to the summer closure, document validation will resume starting August 28, 2026. We apologize for any inconvenience.

Files

514385.pdf (133.07 KB)

Document type

Article

Version

Accepted version

Publication date

2003-08-01

All rights reserved

Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/183689

Influence of talc dose on extrapleural talc dissemination after talc slurry pleurodesis

Journal Title

Authors

Director/Tutor

Journal ISSN

Volume Title

Related resource

https://doi.org/10.1164/rccm.200207-767OC

Abstract

This study was designed to ascertain, in a rabbit model, extrapleural talc deposition and the related inflammatory response after talc slurry pleurodesis with two clinical doses, 200 and 50 mg/kg. Histopathologic evaluations revealed that whereas numerous rabbits receiving a high dose had talc in the ipsilateral (70%) and contralateral (55%) lung, mediastinum (90%), pericardium (30%), and liver (25%), a small number of animals treated with a low dose showed talc in the ipsilateral lung (10%) and mediastinum (20%) and none in the contralateral lung, pericardium, or liver. Hematologic and immunocytochemical analyses showed that a systemic inflammatory response develops shortly after pleurodesis with a high talc dose involving massive accumulation of neutrophils and macrophages in lung tissue. Zymography also revealed that the pulmonary expression of matrix metalloproteinases 2 and 9 was up-regulated in both lungs in a dose-dependent manner soon after talc instillation. Furthermore, microscopic examination of lung specimens revealed that the higher the dose of talc, the greater the development of both fibrotic visceral pleural thickening and foreign-body granulomas. These findings show pleurodesis with a high talc dose to be associated with an increased risk of extrapleural talc deposition, which may originate undesirable acute and chronic inflammatory responses.

Subject

Inflamació, Pulmó, Macròfags

Subject (English)

Inflammation, Lung, Macrophages

Citation

Collections

Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)

Citation

MONTES CASTILLO, Juan Francisco, et al. Influence of talc dose on extrapleural talc dissemination after talc slurry pleurodesis. American Journal of Respiratory and Critical Care Medicine. 2003. Vol. 168, num. 3, pags. 348-355. ISSN 1073-449X. [consulted: 8 of August of 2026]. Available at: https://hdl.handle.net/2445/183689

Export metadata

JSON - METS

Share record