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2021-10-25

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cc-by-nc-nd (c) Izquierdo, Luis et al., 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/230138

Spike-based COVID-19 immunization increases antibodies to nucleocapsid antigen

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Recurs relacionat

https://doi.org/10.1016/j.trsl.2021.10.004

Resum

Antibodies to the nucleocapsid (N) antigen are suggested to be used to monitor infections after COVID-19 vaccination, as first generation subunit vaccines are based on the spike (S) protein. We used multiplex immunoassays to simultaneously measure antibody responses to different fragments of the SARS-CoV-2 S and N antigens for evaluating the immunogenicity of the mRNA-1273 (Spykevax) and the BNT162b2 (Comirnaty) vaccines in 445 health care workers. We report a >4-fold increase post-vaccination of IgG levels to the full length (N FL) and C-terminus of N (N CT) in 5.2% and 18.0% of individuals, respectively, and of IgA in 3.6% (N FL) and 9.0% (N CT) of them. The increase in IgG levels and avidity was more pronounced after Spykevax than Comirnaty vaccination (36.2% vs 13.1% for N CT, and 10.6% vs 3.7% for N FL). Data suggest the induction of cross-reactive antibodies against the N CT region after administering these S-based vaccines, and this should be taken into account when using N seropositivity to detect breakthroughs.

Matèries

COVID-19, Anticossos monoclonals

Matèries (anglès)

COVID-19, Monoclonal antibodies

Citació

Col·leccions

Articles publicats en revistes (Medicina)
Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)

Citació

IZQUIERDO, Luis, et al. Spike-based COVID-19 immunization increases antibodies to nucleocapsid antigen. Translational Research. The Journal of Laboratory and Clinical Medicine. Vol.  2021, num. 240, pags. 26-32. ISSN 1931-5244. [consulted: 22 of August of 2026]. Available at: https://hdl.handle.net/2445/230138

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