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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/172779
Nicotinamide Prevents apolipoprotein b-containing lipoprotein oxidation, inflammation and atherosclerosis in apolipoprotein e-deficient mice
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The potential of nicotinamide (NAM) to prevent atherosclerosis has not yet been examined. This study investigated the effect of NAM supplementation on the development of atherosclerosis in a mouse model of the disease. The development of aortic atherosclerosis was significantly reduced (NAM low dose: 45%; NAM high dose: 55%) in NAM-treated, apolipoprotein (Apo)E-deficient mice challenged with a Western diet for 4 weeks. NAM administration significantly increased (1.8-fold) the plasma concentration of proatherogenic ApoB-containing lipoproteins in NAM high-dose (HD)-treated mice compared with untreated mice. However, isolated ApoB-containing lipoproteins from NAM HD mice were less prone to oxidation than those of untreated mice. This result was consistent with the decreased (1.5-fold) concentration of oxidized low-density lipoproteins in this group. Immunohistochemical staining of aortas from NAM-treated mice showed significantly increased levels of IL-10 (NAM low-dose (LD): 1.3-fold; NAM HD: 1.2-fold), concomitant with a significant decrease in the relative expression of TNFα (NAM LD: −44%; NAM HD: −57%). An improved anti-inflammatory pattern was reproduced in macrophages cultured in the presence of NAM. Thus, dietary NAM supplementation in ApoE-deficient mice prevented the development of atherosclerosis and improved protection against ApoB-containing lipoprotein oxidation and aortic inflammation.
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MÉNDEZ-LARA, Karen alejandra, LETELIER TORRES, Nicole, FARRÉ, Núria, DIARTE-AÑAZCO, Elena m.g., NIETO-NICOLAU, Nuria, RODRÍGUEZ-MILLÁN, Elisabeth, SANTOS, David, PALLARÈS, Víctor, ESCOLÀ GIL, Joan carles, VÁZQUEZ DEL OLMO, Tania, LERMA, Enrique, CAMACHO, Mercedes, CASAROLI MARANO, Ricardo pedro, VALLEDOR FERNÁNDEZ, Annabel, BLANCO-VACA, Francisco, JULVE, Josep. Nicotinamide Prevents apolipoprotein b-containing lipoprotein oxidation, inflammation and atherosclerosis in apolipoprotein e-deficient mice. _Antioxidants_. 2020. Vol. 9, núm. 11, pàgs. 1162. [consulta: 21 de gener de 2026]. ISSN: 2076-3921. [Disponible a: https://hdl.handle.net/2445/172779]