Document type
ArticleVersion
Published versionPublication date
All rights reserved
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/18679
Lymphocyte populations in liver biopsy specimens from patients with chronic liver disease
Journal Title
Director/Tutor
Journal ISSN
Volume Title
Related resource
Abstract
The characterisation of lymphocytes from liver biopsies indicates that 'activated' T lymphocytes are present in the liver in alcohol induced hepatitis, chronic active hepatitis (HBS+ve and -ve), and in primary biliary cirrhosis but not in inactive cirrhosis, chronic persistent hepatitis, extrahepatic and drug induced cholestasis. A greater percentage of lymphocytes bear Fc-receptors in chronic active hepatitis than in alcohol induced hepatitis or cholestatic liver disease. The concentration of 'activated' T cells in the peripheral blood in all groups studied was within the normal range, suggesting that the 'activated' T cells found in the liver were reacting to either native or foreign antigens within the liver. The data on Fc-receptor bearing cells are consistent with the involvement of antibody assisted K cell mediated cytotoxicity in chronic active hepatitis.
Subject
Subject (English)
Citation
Collections
Citation
SÁNCHEZ TAPIAS, José M. (José María), THOMAS, H. C. and SHERLOCK, Sheila. Lymphocyte populations in liver biopsy specimens from patients with chronic liver disease. Gut. 1977. Vol. 18, num. 6, pags. 472-475. ISSN 0017-5749. [consulted: 15 of June of 2026]. Available at: https://hdl.handle.net/2445/18679