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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/198073
Systemic regulatory T cells and IL-6 as prognostic factors for anatomical improvement of uveitic macular edema
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Purpose: To investigate whether systemic immune mediators and circulating regulatory T cells (Tregs) could be prognostic factors for anatomic outcomes in macular edema secondary to non-infectious uveitis (UME). Methods: Multicenter, prospective, observational, 12-month follow-up study of 60 patients with UME. Macular edema was defined as central subfield thickness (CST) > 300 μm measured with spectral domain optical coherence tomography (SD-OCT). Serum samples and peripheral blood mononuclear cells (PBMC) were obtained from venous blood extraction at baseline. Serum levels of IL-1β, IL-6, IL-8, IL-17, MCP-1, TNF-α, IL-10, and VEGF were determined by Luminex. Tregs population, defined as CD3+CD4+FoxP3+ in PBMC, was determined by flow cytometry. Main outcome measure was the predictive association between searched mediators and CST sustained improvement, defined as CST < 300 microns or a 20% CST decrease, at 6 months maintained until 12-months compared to baseline levels. Results: Multivariate logistic regression analysis showed an association between CST sustained improvement at 12 months follow-up and IL-6 and Tregs baseline levels. Higher IL-6 levels were associated with less events of UME improvement (OR: 0.67, 95% CI (0.45-1.00), P = 0.042), whereas higher levels of Tregs favored such improvement (OR: 1.25, 95% CI: 1.12-2.56, P = 0.049). Conclusions: Increased levels of Tregs and reduced levels of IL-6 in serum may be prognostic factors of sustained anatomical improvement in UME. These findings could enforce the opportunity to develop more efficient and personalized therapeutic approaches to improve long-term visual prognosis in patients with UME.
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MATAS, Jessica, LLORENÇ, Victor, FONOLLOSA, Alex, DÍAZ VALLE, David, ESQUINAS LÓPEZ, Cristina, SAINZ DE LA MAZA SERRA, María teresa, FIGUERAS ROCA, Marc, ARTARAZ, Joseba, BERASATEGUI, Barbara, MESQUIDA, Marina, ADÁN CIVERA, Alfredo, MOLINS, Blanca. Systemic regulatory T cells and IL-6 as prognostic factors for anatomical improvement of uveitic macular edema. _Frontiers in Immunology_. 2020. Vol. 11, núm. 579005. [consulta: 4 de març de 2026]. ISSN: 1664-3224. [Disponible a: https://hdl.handle.net/2445/198073]