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2020-09-25

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cc-by (c) Matas, Jessica et al., 2020
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/198073

Systemic regulatory T cells and IL-6 as prognostic factors for anatomical improvement of uveitic macular edema

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https://doi.org/10.3389/fimmu.2020.579005

Abstract

Purpose: To investigate whether systemic immune mediators and circulating regulatory T cells (Tregs) could be prognostic factors for anatomic outcomes in macular edema secondary to non-infectious uveitis (UME). Methods: Multicenter, prospective, observational, 12-month follow-up study of 60 patients with UME. Macular edema was defined as central subfield thickness (CST) > 300 μm measured with spectral domain optical coherence tomography (SD-OCT). Serum samples and peripheral blood mononuclear cells (PBMC) were obtained from venous blood extraction at baseline. Serum levels of IL-1β, IL-6, IL-8, IL-17, MCP-1, TNF-α, IL-10, and VEGF were determined by Luminex. Tregs population, defined as CD3+CD4+FoxP3+ in PBMC, was determined by flow cytometry. Main outcome measure was the predictive association between searched mediators and CST sustained improvement, defined as CST < 300 microns or a 20% CST decrease, at 6 months maintained until 12-months compared to baseline levels. Results: Multivariate logistic regression analysis showed an association between CST sustained improvement at 12 months follow-up and IL-6 and Tregs baseline levels. Higher IL-6 levels were associated with less events of UME improvement (OR: 0.67, 95% CI (0.45-1.00), P = 0.042), whereas higher levels of Tregs favored such improvement (OR: 1.25, 95% CI: 1.12-2.56, P = 0.049). Conclusions: Increased levels of Tregs and reduced levels of IL-6 in serum may be prognostic factors of sustained anatomical improvement in UME. These findings could enforce the opportunity to develop more efficient and personalized therapeutic approaches to improve long-term visual prognosis in patients with UME.

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Marcadors bioquímics, Citometria de fluxe, Edema, Inflamació

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Biochemical markers, Flow cytometry, Edema, Inflammation

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Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)

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MATAS, Jessica, et al. Systemic regulatory T cells and IL-6 as prognostic factors for anatomical improvement of uveitic macular edema. Frontiers in Immunology. 2020. Vol. 11, num. 579005. ISSN 1664-3224. [consulted: 18 of August of 2026]. Available at: https://hdl.handle.net/2445/198073

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