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2021-09-24

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cc-by (c) Espona, Mercè et al., 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/180527

Impact of generic entry on hospital antimicrobial use: a retrospective quasi-experimental interrupted time series analysis

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Recurs relacionat

https://doi.org/10.3390/antibiotics10101149

Resum

Background: the impact of antimicrobials generic entry (GE) is controversial. Their introduction could provide an economic benefit yet may also increase their consumption, leadingto a higher risk of resistance. Our aim was to analyze the impact of GE on trends of antimicrobialconsumption in an acute-care hospital. Methods: a retrospective quasi-experimental interrupted timeseries analysis was conducted at a 400-bed tertiary hospital in Barcelona, Spain. All antimicrobials forsystemic use for which a generic product entered the hospital from January 2000 to December 2019 were included. Antimicrobial consumption was expressed as DDD/100 bed days. Results: after GE, the consumption of cefotaxime (0.09,p< 0.001), meropenem (0.54,p< 0.001), and piperacillin-tazobactam (0.13,p< 0.001) increased, whereas the use of clindamycin (−0.03,p< 0.001) anditraconazole (−0.02,p= 0.01) was reduced. An alarming rise in cefepime (0.004), daptomycin (1.02),and cloxacillin (0.05) prescriptions was observed, despite not achieving statistical significance. Onthe contrary, the use of amoxicillin (−0.07), ampicillin (−0.02), cefixime (−0.06), fluconazole (−0.13),imipenem-cilastatin (−0.50) and levofloxacin (−0.35) decreased. These effects were noticed beyondthe first year post GE. Conclusions: GE led to an increase in the consumption of broad-spectrummolecules. The potential economic benefit of generic antibiotics could be diluted by an increase inresistance. Antimicrobial stewardship should continue to monitor these molecules despite GE.

Matèries

Antibiòtics, Hospitals, Ús terapèutic

Matèries (anglès)

Antibiotics, Hospitals, Therapeutic use

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Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)

Citació

ESPONA, Mercè, et al. Impact of generic entry on hospital antimicrobial use: a retrospective quasi-experimental interrupted time series analysis. Antibiotics. 2021. Vol. 10, num. 10, pags. 1149-1155. ISSN 2079-6382. [consulted: 8 of August of 2026]. Available at: https://hdl.handle.net/2445/180527

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