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Guerrero-PerezF.pdf (792.26 KB)

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2020-06-01

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cc by (c) Guerrero Pérez et al., 2020
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/171943

Long-term effects in bone mineral density after different bariatric procedures in patients with type 2 diabetes: outcomes of a randomized clinical trial

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https://doi.org/10.3390/jcm9061830

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There is scant evidence of the long-term effects of bariatric surgery on bone mineral density (BMD). We compared BMD changes in patients with severe obesity and type 2 diabetes (T2D) 5 years after randomization to metabolic gastric bypass (mRYGB), sleeve gastrectomy (SG) and greater curvature plication (GCP). We studied the influence of first year gastrointestinal hormone changes on final bone outcomes. Forty-five patients, averaging 49.4 (7.8) years old and body mass index (BMI) 39.4 (1.9) kg/m(2), were included. BMD at lumbar spine (LS) was lower after mRYGB compared to SG and GCP: 0.89 [0.82;0.94] vs. 1.04 [0.91;1.16] vs. 0.99 [0.89;1.12],p= 0.020. A higher percentage of LS osteopenia was present after mRYGB 78.6% vs. 33.3% vs. 50.0%, respectively. BMD reduction was greater in T2D remitters vs. non-remitters. Weight at fifth year predicted BMD changes at the femoral neck (FN) (adjustedR(2): 0.3218;p= 0.002), and type of surgery (mRYGB) and menopause predicted BMD changes at LS (adjustedR(2): 0.2507;p< 0.015). In conclusion, mRYGB produces higher deleterious effects on bone at LS compared to SG and GCP in the long-term. Women in menopause undergoing mRYGB are at highest risk of bone deterioration. Gastrointestinal hormone changes after surgery do not play a major role in BMD outcomes.

Matèries

Densitat mineral òssia, Cirurgia de l'obesitat

Matèries (anglès)

Bone density, Obesity surgery

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Ciències Fisiològiques)

Citació

GUERRERO PÉREZ, Fernando, CASAJOANA, Anna, GÓMEZ VAQUERO, Carmen, VIRGILI, Núria, LÓPEZ URDIALES, Rafael, HERNÁNDEZ MONTOLIU, Laura, PUJOL GEBELLI, Jordi, OSORIO, Javier, PRATS, Anna, PUJOL GEBELLI, Jordi, PÉREZ MARAVER, Manuel, FERNÁNDEZ VELEDO, Sonia, VENDRELL, Joan, VILARRASA, Nuria. Long-term effects in bone mineral density after different bariatric procedures in patients with type 2 diabetes: outcomes of a randomized clinical trial. _Journal of Clinical Medicine_. 2020. Vol. 9, núm. 6. [consulta: 25 de febrer de 2026]. [Disponible a: https://hdl.handle.net/2445/171943]

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