Lipid Nanocarriers for Hyperproliferative Skin Diseases

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dc.contributor.authorSouto, Eliana B.
dc.contributor.authorde Souza, Ana Luiza R.
dc.contributor.authorDos Santos, Fernanda K.
dc.contributor.authorSánchez-López, E. (Elena)
dc.contributor.authorCano Fernández, Amanda
dc.contributor.authorZielinska, Aleksandra
dc.contributor.authorStaszewski, Rafal
dc.contributor.authorKarczewski, Jacek
dc.contributor.authorGremiao, Maria Palmira D
dc.contributor.authorChorilli, Marlus
dc.date.accessioned2022-03-03T12:21:16Z
dc.date.available2022-03-03T12:21:16Z
dc.date.issued2021
dc.date.updated2022-03-03T12:21:16Z
dc.description.abstractHyperproliferative skin diseases (HSD) are a group of diseases that include cancers, pre-cancerous lesions and diseases of unknown etiology that present different skin manifestations in terms of the degree and distribution of the injuries. Anti-proliferative agents used to treat these diseases are so diverse, including 5-aminolevulinic acid, 5-fluorouracil, imiquimod, methotrexate, paclitaxel, podophyllotoxin, realgar, and corticosteroids in general. These drugs usually have low aqueous solubility, which consequently decreases skin permeation. Thus, their incorporation in lipid nanocarriers has been proposed with the main objective to increase the effectiveness of topical treatment and reduce side effects. This manuscript aims to describe the advantages of using lipid nanoparticles and liposomes that can be used to load diversity of chemically different drugs for the treatment of HSD. Keywords: lipid nanoparticles; liposomes; hyperproliferative skin diseases; antiproliferative drugs; skin cancer
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec718905
dc.identifier.issn2072-6694
dc.identifier.urihttps://hdl.handle.net/2445/183722
dc.language.isoeng
dc.publisherMDPI
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.3390/cancers13225619
dc.relation.ispartofCancers, 2021, vol. 13, num. 5619
dc.relation.urihttps://doi.org/10.3390/cancers13225619
dc.rightscc-by (c) Souto, Eliana B. et al., 2021
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceArticles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
dc.subject.classificationPell
dc.subject.classificationNanopartícules
dc.subject.classificationCàncer de pell
dc.subject.otherSkin
dc.subject.otherNanoparticles
dc.subject.otherSkin cancer
dc.titleLipid Nanocarriers for Hyperproliferative Skin Diseases
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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