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Liver International - 2025 - Battistella - HBcrAg and cirB‐RNA Do Not Predict Clinical and Virological Outcomes in Patients.pdf (513.96 KB)

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2025-04-21

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/227670

HBcrAg and cirB-RNA Do Not Predict Clinical and Virological Outcomes in Patients With HBeAg-Negative Chronic Infection

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https://doi.org/10.1111/liv.70072

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Background & Aims: Predicting clinical and virological outcomes in HBeAg-negative (HBeAg-neg) chronic infection often requires long-term monitoring. Our study explored whether a single measurement of quantitative HBsAg (qHBsAg), HBV core-related antigen (HBcrAg), and circulating HBV RNA (cirB-RNA) can define the natural course of untreated HBeAg-neg chronic infection patients. Methods: To this aim, we included 128 na & iuml;ve HBeAg-neg chronic infection patients, stratified according to qHBsAg levels in: (1) 10-1000 IU/mL, (2) 1000-10 000 IU/mL, and (3) > 10 000 IU/mL. Results: HBcrAg and cirB-RNA were detected in 27% and 19% of patients with qHBsAg > 1000 IU/mL but rarely detected in patients with qHBsAg < 1000 IU/mL. After a median follow-up of 5.1 years, 9.4% of patients lost HBsAg, and 8.5% experienced an increase in HBV DNA > 2000 IU/mL. qHBsAg < 1000 IU/mL was the only factor independently associated with functional cure. Conclusions: In untreated HBeAg-neg chronic infection patients, single-point cirB-RNA and HBcrAg do not offer additional predictive value over qHBsAg < 1000 IU/mL for spontaneous HBsAg loss.

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Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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BATTISTELLA, Sara, LEONEL COUTO, Thais, POCURULL APARICIO, Anna, RODRÍGUEZ TAJES, Sergio, SÀEZ PALMA, Maria, RANDO-SEGURA, Ariadna, MARIÑO MENDEZ, Zoe, TABERNERO, David, HURTADO, Juan carlos, CORTESE, Maria francesca, PÉREZ DEL PULGAR GALLART, Sofía, LENS GARCÍA, Sabela, FORNS BERNHARDT, Xavier. HBcrAg and cirB-RNA Do Not Predict Clinical and Virological Outcomes in Patients With HBeAg-Negative Chronic Infection. _Liver International_. 2025. Vol.  45, núm. 5, pàgs. e70072. [consulta: 28 de febrer de 2026]. ISSN: Battistella, Sara; Leonel, Thais; Pocurull, Anna; Rodriguez-Tajes, Sergio; Saez-Palma, Maria; Rando-Segura, Ariadna; Marino, Zoe; Tabernero, David; Hu (2025). HBcrAg and cirB-RNA Do Not Predict Clinical and Virological Outcomes in Patients With HBeAg-Negative Chronic Infection. Liver International, 45(5), e70072-. DOI: 10.1111/liv.70072. [Disponible a: https://hdl.handle.net/2445/227670]

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