Amb motiu del tancament d'estiu, la validació de documents es reprendrà a partir del 28 d'agost de 2026. Disculpeu les molèsties.
Con motivo del cierre de verano, la validación de documentos se reanudará a partir del 28 de agosto de 2026. Disculpad las molestias
Due to the summer closure, document validation will resume starting August 28, 2026. We apologize for any inconvenience.

Fitxers

238678.pdf (6.04 MB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2021-03-05

Llicència de publicació

cc-by (c) Mirra, S et al., 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/229712

ARMCX3 mediates susceptibility to hepatic tumorigenesis promoted by dietary lipotoxicity.

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.3390/cancers13051110

Resum

Abstract: ARMCX3 is encoded by a member of the Armcx gene family and is known to be involved in nervous system development and function. We found that ARMCX3 is markedly upregulated in mouse liver in response to high lipid availability, and that hepatic ARMCX3 is upregulated in pa-tients with NAFLD and hepatocellular carcinoma (HCC). Mice were subjected to ARMCX3 in-validation (inducible ARMCX3 knockout) and then exposed to a high-fat diet and diethylnitrosa-mine-induced hepatocarcinogenesis. The effects of experimental ARMCX3 knockdown or overex-pression in HCC cell lines were also analyzed. ARMCX3 invalidation protected mice against high-fat-diet-induced NAFLD and chemically induced hepatocarcinogenesis. ARMCX3 invalida-tion promoted apoptotic cell death and macrophage infiltration in livers of diethylnitrosa-mine-treated mice maintained on a high-fat diet. ARMCX3 downregulation reduced the viability, clonality and migration of HCC cell lines, whereas ARMCX3 overexpression caused the reciprocal effects. SOX9 was found to mediate the effects of ARMCX3 in hepatic cells, with the SOX9 inter-action required for the effects of ARMCX3 on hepatic cell proliferation. In conclusion, ARMCX3 is identified as a novel molecular actor in liver physiopathology and carcinogenesis. ARMCX3 downregulation appears to protect against hepatocarcinogenesis, especially under conditions of high dietary lipid-mediated hepatic insult.

Matèries

Càncer de fetge, Mort cel·lular

Matèries (anglès)

Liver cancer, Cell death

Citació

Col·leccions

Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)

Citació

MIRRA, Serena, et al. ARMCX3 mediates susceptibility to hepatic tumorigenesis promoted by dietary lipotoxicity. Cancers. 2021. Vol. 13, num. 5, pags. 1110-1131. ISSN 2072-6694. [consulted: 7 of August of 2026]. Available at: https://hdl.handle.net/2445/229712

Exportar metadades

JSON - METS

Compartir registre