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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/34586
An enantioselective entry to cis-perhydroisoquinolines
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An enantioselective route to cis-perhydroisoquinolines, involving a cyclocondensation reaction of (R)-phenylglycinol with a racemic oxoester, a stereoselective conjugate addition to an unsaturated bicyclic lactam, and the closure of the carbocyclic ring by a ring-closing metathesis as the key steps is reported. This route allows the preparation of 3-cyano derivatives as well as cis-octahydroisoquinolines bearing a quaternary center at the C4-position.
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AMAT TUSÓN, Mercedes, et al. An enantioselective entry to cis-perhydroisoquinolines. Organic Letters. 2005. Vol. 7, num. 17, pags. 3653-3656. ISSN 1523-7060. [consulted: 14 of October of 2026]. Available at: https://hdl.handle.net/2445/34586