An enantioselective entry to cis-perhydroisoquinolines

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dc.contributor.authorAmat Tusón, Mercedes
dc.contributor.authorPérez Bosch, Maria
dc.contributor.authorMinaglia, Annamaria Tania
dc.contributor.authorCasamitjana i Badia, Núria
dc.contributor.authorBosch Cartes, Joan
dc.date.accessioned2013-04-15T16:48:33Z
dc.date.available2013-04-15T16:48:33Z
dc.date.issued2005-07-25
dc.date.updated2013-04-15T16:48:33Z
dc.description.abstractAn enantioselective route to cis-perhydroisoquinolines, involving a cyclocondensation reaction of (R)-phenylglycinol with a racemic oxoester, a stereoselective conjugate addition to an unsaturated bicyclic lactam, and the closure of the carbocyclic ring by a ring-closing metathesis as the key steps is reported. This route allows the preparation of 3-cyano derivatives as well as cis-octahydroisoquinolines bearing a quaternary center at the C4-position.
dc.format.extent4 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec568510
dc.identifier.issn1523-7060
dc.identifier.urihttps://hdl.handle.net/2445/34586
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.relation.isformatofVersió postprint del document publicat a: http://dx.doi.org/10.1021/ol051242c
dc.relation.ispartofOrganic Letters, 2005, vol. 7, num. 17, p. 3653-3656
dc.relation.urihttp://dx.doi.org/10.1021/ol051242c
dc.rights(c) American Chemical Society , 2005
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
dc.subject.classificationIsoquinolina
dc.subject.otherIsoquinoline
dc.titleAn enantioselective entry to cis-perhydroisoquinolines
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion

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Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)