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2022-02-25

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cc by-nc-nd (c) Verdolini, Norma et al., 2022
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/190776

Prodromal phase: Differences in prodromal symptoms, risk factors and markers of vulnerability in first episode mania versus first episode psychosis with onset in late adolescence or adulthood

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https://doi.org/10.1111/acps.13415

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Objective: This study was aimed at identifying differences in the prodromal symptoms and their duration, risk factors and markers of vulnerability in patients presenting a first episode mania (FEM) or psychosis (FEP) with onset in late adolescence or adulthood in order to guide tailored treatment strategies. Methods: Patients with a FEM or FEP underwent a clinical assessment. Prodromes were evaluated with the Bipolar Prodrome Symptom Scale-Retrospective (BPSS-R). Chi-squared tests were conducted to assess specific prodromal symptoms, risk factors or markers of vulnerability between groups. Significant prodromal symptoms were entered in a stepwise forward logistic regression model. The probabilities of a gradual versus rapid onset pattern of the prodromes were computed with logistic regression models. Results: The total sample included 108 patients (FEM = 72, FEP = 36). Social isolation was associated with the prodromal stage of a FEP whilst Increased energy or goal-directed activity with the prodrome to a FEM. Physically slowed down presented the most gradual onset whilst Increased energy presented the most rapid. The presence of obstetric complications and difficulties in writing and reading during childhood were risk factors for FEP. As for markers of vulnerability, impairment in premorbid adjustment was characteristic of FEP patients. No specific risk factor or marker of vulnerability was identified for FEM. Conclusion: Early characteristics differentiating FEP from FEM were identified. These findings might help shape early identification and preventive intervention programmes.

Matèries

Psicosi, Trastorn bipolar, Factors de risc en les malalties, Psicosi en els adolescents, Adults, Símptomes

Matèries (anglès)

Psychoses, Manic-depressive illness, Risk factors in diseases, Psychoses in adolescence, Adulthood, Symptoms

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Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

VERDOLINI, Norma, BORRÀS, Roger, SPARACINO, Giulio, GARRIGA, Marina, SAGUÉ VILAVELLA, Maria, MADERO GÓMEZ, Santiago, PALACIOS GARRÁN, Roberto, SERRA NAVARRO, Maria, FORTE, Maria florencia, SALAGRE MUÑOZ, Estela, AEDO, Alberto, SALGADO PINEDA, Pilar, MONTORO SALVATIERRA, Irene, SÁNCHEZ GISTAU, Vanessa, POMAROL-CLOTET, Edith, RAMOS QUIROGA, Josep antoni, CARVALHO, André f., GARCÍA RIZO, Clemente, UNDURRAGA FOURCADE, Juan pablo, REINARES, María, MARTINEZ ARAN, Anabel, BERNARDO ARROYO, Miquel, VIETA I PASCUAL, Eduard, PACCHIAROTTI, Isabella, AMORETTI GUADALL, Silvia. Prodromal phase: Differences in prodromal symptoms, risk factors and markers of vulnerability in first episode mania versus first episode psychosis with onset in late adolescence or adulthood. _Acta Psychiatrica Scandinavica_. 2022. Vol. 146, núm. 1, pàgs. 36-50. [consulta: 15 de gener de 2026]. ISSN: 0001-690X. [Disponible a: https://hdl.handle.net/2445/190776]

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