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2026-02-09

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cc-by (c) Schenberg, Louise et al., 2026
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/229269

Sensory-cell population integrity required to preserve minimal and normal vestibulo-ocular reflexes reveals the critical role of type I hair cells in canal- and otolith-specific functions

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Recurs relacionat

https://doi.org/10.1523/ENEURO.0303-25.2026

Resum

Vestibular dysfunction constitutes a major medical concern, and regeneration of hair cells (HC) is a primary target of gene therapy aimed at restoring vestibular functions. Thus far, therapeutic trials in animal models targeting vestibular loss associated with genetic diseases have yielded variable and partial results, and the functional identity and quantity of HCs required to restore minimal or normal vestibular function remain undefined. Indeed, direct comparisons between structural pathology and quantitative assessments of vestibular dysfunctions are lacking in humans and are rather limited in animal models, representing a significant gap in current knowledge. Here, we present an innovative methodology to bridge the gap between HC integrity and functional vestibular loss in individual mice of either sex. Gradual vestibular deficits were induced through a dose-dependent ototoxic lesion, quantified with canal or utricular-specific vestibulo-ocular reflex tests, and were then correlated in all individuals with the loss of type I and type II HCs in different regions of ampulla and macula. Our findings reveal that the structure-function relationship is nonlinear, with lower bound of approximately 50% of HCs necessary to retain minimal vestibular function, and threshold exceeding 80% to preserve normal function, thus shedding light on population coding mechanisms for vestibular response. Our data further support the decisive role of type I, rather than type II, HC in the tested VOR functions.

Matèries

Immunogenètica, Cèl·lules acústiques, Receptors sensitius

Matèries (anglès)

Immunogenetics, Hair cells, Sensory receptors

Citació

Col·leccions

Articles publicats en revistes (Ciències Fisiològiques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Institut de Neurociències (UBNeuro))

Citació

SCHENBERG, Louise, et al. Sensory-cell population integrity required to preserve minimal and normal vestibulo-ocular reflexes reveals the critical role of type I hair cells in canal- and otolith-specific functions. eNeuro. 2026. Vol. 13, num. 2, pags. 1-16. ISSN 2373-2822. [consulted: 19 of August of 2026]. Available at: https://hdl.handle.net/2445/229269

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