Document type
ArticleVersion
Accepted versionPublication date
All rights reserved
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/222614
AIM/CD5L: A Key protein in the control of immune homeostasis and inflammatory disease
Journal Title
Director/Tutor
Journal ISSN
Volume Title
Related resource
Abstract
CD5L, a soluble protein belonging to the scavenger receptor cysteine-rich superfamily, is expressed mostly by macrophages in both lymphoid and inflamed tissues. The expression of this protein is transcriptionally controlled by liver X receptors, members of the nuclear receptor family that play major roles in lipid homeostasis. Research undertaken over the last decade has uncovered critical roles of CD5L as a pattern recognition receptor of bacterial and fungal components and in the control of key mechanisms in inflammatory responses, with involvement in processes such as infection, atherosclerosis, and cancer. In this review, we summarize the current knowledge of CD5L, its roles at the intersection between lipid homeostasis and immune response, and its potential use as a diagnostic biomarker in a variety of diseases, such as tuberculosis and liver cirrhosis.
Subject (English)
Citation
Citation
SANJURJO, Lucía, et al. AIM/CD5L: A Key protein in the control of immune homeostasis and inflammatory disease. Journal of Leukocyte Biology. 2015. Vol. 98, num. 2, pags. 173-184. ISSN 0741-5400. [consulted: 17 of August of 2026]. Available at: https://hdl.handle.net/2445/222614