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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/190792
Preoperative omega-6/omega-3 fatty acid ratio could predict postoperative outcomes in patients with surgically resected non-small-cell lung cancer
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Introduction: The aim of this study was to determine whether preoperative nutritional status and inflammatory status, specifically polyunsaturated acids and the omega 6/3 ratio, would affect postoperative outcomes and complications in patients with lung cancer undergoing lung resection. Methods: This prospective observational study included 68 patients with early-stage non-small-cell lung cancer who were candidates for radical surgery. A complete nutritional assessment was performed. The primary study variable was postoperative complications and mortality in the first 30 days. Descriptive, bivariate, and logistic regression analyses were carried out. Results: A total of 50 men (73.53%) and 18 women (26.47%) underwent surgery, with a median age of 64.2 (±9.74) years. The mean omega 6/3 ratio was 17.39 (±9.45). A complication occurred in 39.7% of the study sample (n = 27), the most common being persistent air leak in 23.53% (n = 16). After performing the bivariate analysis, the only variable that remained significant was the omega 6/3 ratio; we observed that it had a prognostic value for persistent air leak (p = 0.001) independent of age, sex, comorbidity, preoperative respiratory function, and approach or type of surgery. The remaining nutritional and inflammatory markers did not have a statistically significant association (p > 0.05) with postoperative complications. However, this significance was not maintained in the multivariate analysis by a small margin (p = 0.052; 95% CI: 0.77-1.41). Conclusions: Omega 6/3 ratio may be a prognostic factor for air leak, independent of the patient's clinical and pathological characteristics.
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DÉNIZ, Carlos, RABA-PARODI, Carla, GARCÍA-RAIMUNDO, Eva, MACÍA, Ivan, RIVAS, Francisco, UREÑA LLUVERAS, Anna, MUÑOZ, Anna, MORENO, Camilo, SERRATOSA, Ines, MASUET AUMATELL, Cristina, ESCOBAR, Ignacio, RAMOS IZQUIERDO, Ricard. Preoperative omega-6/omega-3 fatty acid ratio could predict postoperative outcomes in patients with surgically resected non-small-cell lung cancer. _Current Oncology_. 2022. Vol. 29, núm. 7086-7098. [consulta: 23 de gener de 2026]. ISSN: 1198-0052. [Disponible a: https://hdl.handle.net/2445/190792]