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2016-07-20

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/101546

Whole genome sequencing to evaluate the resistance landscape following antimalarial treatment failure with fosmidomycin-clindamycin

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http://dx.doi.org/10.1093/infdis/jiw304

Resum

Novel antimalarial therapies are needed in the face of emerging resistance to artemisinin combination therapies. A previous study found a high cure rate in Mozambican children with uncomplicated Plasmodium falciparum malaria 7 days post treatment with a fosmidomycin-clindamycin combination. However, 28-day cure rates were low (45.9%), due to parasite recrudescence. We sought to identify any genetic changes underlying parasite recrudescence. To this end, we utilized a selective whole genome amplification method to amplify parasite genomes from blood spot DNA samples. Parasite genomes from pre-treatment and post-recrudescence samples were subjected to whole genome sequencing to identify nucleotide variants. We find that our data do not support the existence of a genetic change responsible for recrudescence following fosmidomycin-clindamycin treatment. Additionally, we find that previously described resistance alleles for these drugs do not represent biomarkers of recrudescence. Future studies should continue to optimize fosmidomycin combinations for use as antimalarial therapies.

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Malària, Plasmodium falciparum, Vacuna de la malària

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Malaria, Plasmodium falciparum, Malaria vaccine

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Articles publicats en revistes (ISGlobal)

Citació

GUGGISBERG, Ann m., SUNDARARAMAN, Sesh a., LANASPA, Miguel, MORALEDA REDECILLA, Cinta, GONZÁLEZ, Raquel, MAYOR APARICIO, Alfredo gabriel, CISTERÓ, Pau, HUTCHINSON, David, KREMSNER, Peter g., HAHN, Beatrice h., BASSAT ORELLANA, Quique, ODOM, Audrey r.. Whole genome sequencing to evaluate the resistance landscape
                following antimalarial treatment failure with
                fosmidomycin-clindamycin. _The Journal of Infectious Diseases_. 2016. [consulta: 20 de gener de 2026]. ISSN: 0022-1899. [Disponible a: https://hdl.handle.net/2445/101546]

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