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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/178638
Caveolin-1 in sarcomas: friend or foe?
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Sarcomas represent a heterogeneous group of tumors with a complex and difficult reproducible classification. Their pathogenesis is poorly understood and there are few effective treatment options for advanced disease. Caveolin-1 is a multifunctional scaffolding protein with multiple binding partners that regulates multiple cancer-associated processes including cellular transformation, tumor growth, cell death and survival, multidrug resistance, angiogenesis, cell migration and metastasis. However, ambiguous roles have been ascribed to caveolin-1 in signal transduction and cancer, including sarcomas. In particular, evidence indicating that caveolin-1 function is cell context dependent has been repeatedly reported. Caveolin-1 appears to act as a tumor suppressor protein at early stages of cancer progression. In contrast, a growing body of evidence indicates that caveolin-1 is up-regulated in several multidrug-resistant and metastatic cancer cell lines and human tumor specimens. This review is focused on the role of caveolin-1 in several soft tissue and bone sarcomas and discusses the use of this protein as a potential diagnostic and prognostic marker and as a therapeutic target.
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SÁINZ JASPEADO, Miguel guillermo, MARTÍN LIBERAL, Juan jesús, LAGARES TENA, Laura, MATEO LOZANO, Silvia, GARCÍA DEL MURO SOLANS, Xavier, TIRADO, Oscar m.. Caveolin-1 in sarcomas: friend or foe?. _Oncotarget_. 2011. Vol. 2, núm. 4, pàgs. 305-312. [consulta: 11 de febrer de 2026]. ISSN: 1949-2553. [Disponible a: https://hdl.handle.net/2445/178638]