Files
Document type
ArticleVersion
Published versionPublication date
Publication license
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/150092
Synthesis and antiproliferative activity of novel heterocyclic Glycyrrhetinic acid derivatives
Journal Title
Director/Tutor
Journal ISSN
Volume Title
Related resource
Abstract
A new series of glycyrrhetinic acid derivatives has been synthesized via the introduction of different heterocyclic rings conjugated with an α,β-unsaturated ketone in its ring A. These new compounds were screened for their antiproliferative activity in a panel of nine human cancer cell lines. Compound 10 was the most active derivative, with an IC50 of 1.1 µM on Jurkat cells, which is 96-fold more potent than that of glycyrrhetinic acid, and was 4-fold more selective toward that cancer cell line. Further biological studies performed in Jurkat cells showed that compound 10 is a potent inducer of apoptosis that activates both the intrinsic and extrinsic pathways.
Citation
Citation
ALHO, Daniela P.S., et al. Synthesis and antiproliferative activity of novel heterocyclic Glycyrrhetinic acid derivatives. Molecules. 2019. Vol. 24, num. 4, pags. 766. ISSN 1420-3049. [consulted: 9 of June of 2026]. Available at: https://hdl.handle.net/2445/150092