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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/150092
Synthesis and antiproliferative activity of novel heterocyclic Glycyrrhetinic acid derivatives
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A new series of glycyrrhetinic acid derivatives has been synthesized via the introduction of different heterocyclic rings conjugated with an α,β-unsaturated ketone in its ring A. These new compounds were screened for their antiproliferative activity in a panel of nine human cancer cell lines. Compound 10 was the most active derivative, with an IC50 of 1.1 µM on Jurkat cells, which is 96-fold more potent than that of glycyrrhetinic acid, and was 4-fold more selective toward that cancer cell line. Further biological studies performed in Jurkat cells showed that compound 10 is a potent inducer of apoptosis that activates both the intrinsic and extrinsic pathways.
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ALHO, Daniela p.s., SALVADOR, Jorge a.r., CASCANTE I SERRATOSA, Marta, MARÍN MARTÍNEZ, Silvia. Synthesis and antiproliferative activity of novel heterocyclic Glycyrrhetinic acid derivatives. _Molecules_. 2019. Vol. 24, núm. 4, pàgs. 766. [consulta: 20 de gener de 2026]. ISSN: 1420-3049. [Disponible a: https://hdl.handle.net/2445/150092]