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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/190186
Standardized incidence ratios and risk factors for cancer in patients with systemic sclerosis: Data from the Spanish Scleroderma Registry (RESCLE)
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Aim: Patients with systemic sclerosis (SSc) are at increased risk of cancer, a growing cause of non-SSc-related death among these patients. We analyzed the increased cancer risk among Spanish patients with SSc using standardized incidence ratios (SIRs) and identified independent cancer risk factors in this population. Material and methods: Spanish Scleroderma Registry data were analyzed to determine the demographic characteristics of patients with SSc, and logistic regression was used to identify cancer risk factors. SIRs with 95% confidence intervals (CIs) relative to the general Spanish population were calculated. Results: Of 1930 patients with SSc, 206 had cancer, most commonly breast, lung, hematological, and colorectal cancers. Patients with SSc had increased risks of overall cancer (SIR 1.48, 95% CI 1.36-1.60; P < 0.001), and of lung (SIR 2.22, 95% CI 1.77-2.73; P < 0.001), breast (SIR 1.31, 95% CI 1.10-1.54; P = 0.003), and hematological (SIR 2.03, 95% CI 1.52-2.62; P < 0.001) cancers. Cancer was associated with older age at SSc onset (odds ratio [OR] 1.22, 95% CI 1.01-1.03; P < 0.001), the presence of primary biliary cholangitis (OR 2.35, 95% CI 1.18-4.68; P = 0.015) and forced vital capacity <70% (OR 1.8, 95% CI 1.24-2.70; P = 0.002). The presence of anticentromere antibodies lowered the risk of cancer (OR 0.66, 95% CI 0.45-0.97; P = 0.036). Conclusions: Spanish patients with SSc had an increased cancer risk compared with the general population. Some characteristics, including specific autoantibodies, may be related to this increased risk.
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CARBONELL ABELLA, Cristina, MARCOS, Miguel, GUILLÉN DEL CASTILLO, Alfredo, RUBIO RIVAS, Manuel, ARGIBAY, Ana, MARÍN BALLVÉ, Adela, RODRÍGUEZ PINTÓ, Ignasi, BALDÀ MASMIQUEL, Maria, CALLEJAS MORAGA, Eduardo, COLUNGA ARGÜELLES, Dolores, SÁEZ COMET, Luis, GONZÁLEZ ECHÁVARRI, Cristina, ORTEGO CENTENO, Norberto, MARÍ ALFONSO, Begoña, VARGAS HITOS, José antonio, TODOLÍ PARRA, José antonio, TRAPIELLA, Luis, HERRANZ MARÍN, María teresa, FREIRE, Mayka, CASTRO SALOMÓ, Antoni, PERALES FRAILE, Isabel, MADROÑERO VUELTA, Ana belén, SÁNCHEZ GARCÍA, María esther, RUIZ MUÑOZ, Manuel, GONZÁLEZ GARCÍA, Andrés, SÁNCHEZ REDONDO, Jorge, DE LA RED BELLVIS, Gloria, FERNÁNDEZ LUQUE, Alejandra, MUELA MOLINERO, Alberto, LLEDÓ, Gema, TOLOSA VILELLA, Carles, FONOLLOSA PLA, Vicent, CHAMORRO, Antonio javier, SIMEÓN AZNAR, Carmen pilar. Standardized incidence ratios and risk factors for cancer in patients with systemic sclerosis: Data from the Spanish Scleroderma Registry (RESCLE). _Autoimmunity Reviews_. 2022. Vol. 21, núm. 10, pàgs. 103167. [consulta: 20 de gener de 2026]. ISSN: 1873-0183. [Disponible a: https://hdl.handle.net/2445/190186]