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2016-10-01

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cc-by-nc-nd (c) Elsevier B.V., 2016
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/121109

Gut epithelial barrier markers in patients with obstructive sleep apnea

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https://doi.org/10.1016/j.sleep.2016.01.019

Abstract

Background: obstructive sleep apnea (OSA) is now being recognized as an additional contributing factor to the pathogenesis of obesity-related comorbidities. At the same time, there is now increasing evidence to suggest that intestinal wall permeability plays a role in the development of metabolic syndrome. In the present study, circulating zonulin and fatty acid binding protein (I-FABP) were measured in association with metabolic, hepatic, and inflammatory parameters. Results: compared with controls, plasma I-FABP levels were significantly higher in patients with OSA (571 pg/mL [IQR 290-950] vs 396 pg/mL [IQR 234-559], p = 0.04). Zonulin levels were similar between groups. Significant relationships were observed between zonulin levels and waist circumference (p < 0.05), glucose (p < 0.05), and insulin (p < 0.05). In addition, in the OSA group, zonulin levels correlated negatively with the mean nocturnal oxygenation saturation (p < 0.05) and positively with total cholesterol (p < 0.05), alanine aminotransferase (ALT) (p < 0.005), aminotransferase (AST) (p < 0.01), gamma glutamyltransferase (GGT) (p < 0.005), and high-sensitivity C-reactive protein (hs-CRP) (p < 0.05). Multivariate analysis showed that associations between zonulin and ALT, AST, and hs-CRP were attenuated, but not eliminated, after adjustment for other variables. Conclusions: the results of this study suggest that OSA is a risk factor for intestinal damage, regardless of metabolic profile, and that intestinal permeability might be a possible contributor to nonalcoholic fatty liver disease in patients with OSA.

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Proteïnes portadores, Fixació de proteïnes, Síndrome metabòlica, Absorció intestinal, Síndromes d'apnea del son, Obesitat

Subject (English)

Carrier proteins, Protein binding, Metabolic syndrome, Intestinal absorption, Sleep apnea syndromes, Obesity

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Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)

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BARCELÓ, Antonia, et al. Gut epithelial barrier markers in patients with obstructive sleep apnea. Sleep Medicine. 2016. Vol. 26, num. 12-15. ISSN 1389-9457. [consulted: 9 of June of 2026]. Available at: https://hdl.handle.net/2445/121109

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