Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió acceptadaData de publicació
Tots els drets reservats
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/174286
Nano-engineering of ketorolac tromethamine platforms for ocular treatment of inflammatory disorders
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Aim: The development and optimization of Ketorolac tromethamine-loaded polylactic-co-glycolic acid nanoparticles (KT-NPs) for the treatment of inflammatory processes of the eye. Materials & methods: KT-NPs were developed by factorial design and characterized by assessing their physicochemical properties. Biopharmaceutical behavior studies, ocular tolerance, anti-inflammatory efficacy and bioavailability tests were performed on pigs. Results: Optimized KT-NPs of 112 nm, narrow distribution with encapsulation efficiency near 100% were obtained. KT release followed the Weibull model and there was significantly greater retention in the cornea and sclera than in the commercial reference. KT-NPs showed no signs of ocular irritancy and similar anti-inflammatory efficacy to the commercial reference. Conclusion: KT-NPs were a suitable alternative for the treatment of inflammatory disorders of the anterior and posterior segments of the eye as an alternative to conventional topical formulations.
Matèries (anglès)
Citació
Citació
MALLANDRICH MIRET, Mireia, CALPENA CAMPMANY, Ana cristina, CLARES NAVEROS, Beatriz, PARRA COCA, Alexander, GARCÍA LÓPEZ, María luisa, SORIANO-RUIZ, José l., Francisco Fernández-Campos. Nano-engineering of ketorolac tromethamine platforms for ocular treatment of inflammatory disorders. _Nanomedicine_. 2021. Vol. 13, núm. 3. [consulta: 18 de abril de 2026]. ISSN: 1743-5889. [Disponible a: https://hdl.handle.net/2445/174286]