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2018-08-24

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cc-by (c) Koistinen, Ville Mikael et al., 2018
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/168071

Interlaboratory Coverage Test on Plant Food Bioactive Compounds and their Metabolites by Mass Spectrometry-Based Untargeted Metabolomics.

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https://doi.org/10.3390/metabo8030046

Abstract

Bioactive compounds present in plant-based foods, and their metabolites derived from gut microbiota and endogenous metabolism, represent thousands of chemical structures of potential interest for human nutrition and health. State-of-the-art analytical methodologies, including untargeted metabolomics based on high-resolution mass spectrometry, are required for the profiling of these compounds in complex matrices, including plant food materials and biofluids. The aim of this project was to compare the analytical coverage of untargeted metabolomics methods independently developed and employed in various European platforms. In total, 56 chemical standards representing the most common classes of bioactive compounds spread over a wide chemical space were selected and analyzed by the participating platforms (n = 13) using their preferred untargeted method. The results were used to define analytical criteria for a successful analysis of plant food bioactives. Furthermore, they will serve as a basis for an optimized consensus method.

Subject

Espectrometria de masses, Fitoquímica, Metabolòmica, Plantes comestibles, Compostos bioactius vegetals, Dieta

Subject (English)

Mass spectrometry, Botanical chemistry, Metabolomics, Edible plants, Plant bioactive compounds, Diet

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Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)

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KOISTINEN, Ville Mikael, et al. Interlaboratory Coverage Test on Plant Food Bioactive Compounds and their Metabolites by Mass Spectrometry-Based Untargeted Metabolomics. Metabolites. 2018. Vol. 8, num. 3, pags. 46. ISSN 2218-1989. [consulted: 13 of August of 2026]. Available at: https://hdl.handle.net/2445/168071

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