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2010

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cc-by (c) Ametller, Elisabet et al., 2010
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/166461

Tumor promoting effects of CD95 signalling in chemoresistant cells

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Recurs relacionat

https://doi.org/10.1186/1476-4598-9-161

Resum

Background: CD95 is a death receptor controlling not only apoptotic pathways but also activating mechanisms promoting tumor growth. During the acquisition of chemoresistance to oxaliplatin there is a progressive loss of CD95 expression in colon cancer cells and a decreased ability of this receptor to induce cell death. The aim of this study was to characterize some key cellular responses controlled by CD95 signaling in oxaliplatin-resistant colon cancer cells. Results: We show that CD95 triggering results in an increased metastatic ability in resistant cells. Moreover, oxaliplatin treatment itself stimulates cell migration and decreases cell adhesion through CD95 activation, since CD95 expression inhibition by siRNA blocks the promigratory effects of oxaliplatin. These promigratory effects are related to the epithelia-to-mesenchymal transition (EMT ) phenomenon, as evidenced by the up-regulation of some transcription factors and mesenchymal markers both in vitro and in vivo. Conclusions: We conclude that oxaliplatin treatment in cells that have acquired resistance to oxaliplatin-induced apoptosis results in tumor-promoting effects through the activation of CD95 signaling and by inducing EMT, all these events jointly contributing to a metastatic phenotype.

Matèries

Càncer, Genètica molecular, Teràpia genètica

Matèries (anglès)

Cancer, Molecular genetics, Gene therapy

Citació

Col·leccions

Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Institut de Biomedicina (IBUB))

Citació

AMETLLER, Elisabet, GARCIA-RECIO, Susana, COSTAMAGNA, Domiziana, MAYORDOMO, Cristina, FERNANDEZ-NOGUEIRA, Patricia, CARBÓ CARBÓ, Neus, PASTOR ARROYO, Eva m., GASCÓN, Pere, ALMENDRO NAVARRO, Vanessa. Tumor promoting effects of CD95 signalling in chemoresistant cells. _Molecular Cancer_. 2010. Vol. 9, núm. 161. [consulta: 23 de gener de 2026]. ISSN: 1476-4598. [Disponible a: https://hdl.handle.net/2445/166461]

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