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2021-03-26

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cc-by (c) Sevilla Hernández, Ana et al., 2021
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/176522

An Esrrb and nanog cell fate regulatory module controlled by feed forward loop interactions

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https://doi.org/10.3389/fcell.2021.630067

Abstract

Cell fate decisions during development are governed by multi-factorial regulatory mechanisms including chromatin remodeling, DNA methylation, binding of transcription factors to specific loci, RNA transcription and protein synthesis. However, the mechanisms by which such regulatory 'dimensions' coordinate cell fate decisions are currently poorly understood. Here we quantified the multi-dimensional molecular changes that occur in mouse embryonic stem cells (mESCs) upon depletion of Estrogen related receptor beta (Esrrb), a key pluripotency regulator. Comparative analyses of expression changes subsequent to depletion of Esrrb or Nanog, indicated that a system of interlocked feed-forward loops involving both factors, plays a central part in regulating the timing of mESC fate decisions. Taken together, our meta-analyses support a hierarchical model in which pluripotency is maintained by an Oct4-Sox2 regulatory module, while the timing of differentiation is regulated by a Nanog-Esrrb module.

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Cèl·lules mare embrionàries, Receptors nuclears (Bioquímica)

Subject (English)

Embryonic stem cells, Nuclear receptors (Biochemistry)

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Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)

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SEVILLA, Ana, et al. An Esrrb and nanog cell fate regulatory module controlled by feed forward loop interactions. Frontiers In Cell And Developmental Biology. 2021. Vol. 9, num. 630067. ISSN 2296-634X. [consulted: 12 of August of 2026]. Available at: https://hdl.handle.net/2445/176522

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