Differential inhibition of the TGF-b signaling pathway in HCC cells using the small molecule inhibitor LY2157299 and the D10 monoclonal antibody against TGF-β receptor Type II

Vista senzilla d'ítem
dc.contributor.authorDituri, Francesco
dc.contributor.authorMazzocca, Antonio
dc.contributor.authorPeidrò, Fernando Juan
dc.contributor.authorPapappicco, Patrizia
dc.contributor.authorFabregat Romero, Isabel
dc.contributor.authorDe Santis, Flavia
dc.contributor.authorParadiso, Angelo
dc.contributor.authorSabbà, Carlo
dc.contributor.authorGiannelli, Gianluigi
dc.date.accessioned2016-04-15T13:57:06Z
dc.date.available2016-04-15T13:57:06Z
dc.date.issued2013
dc.date.updated2016-04-15T13:57:12Z
dc.description.abstractWe investigated blocking the TGF-b signaling pathway in HCC using two small molecule inhibitors (LY2157299, LY2109761) and a neutralizing humanized antibody (D10) against TGF-bRII. LY2157299 and LY2109761 inhibited HCC cell migration on Laminin-5, Fibronectin, Vitronectin, Fibrinogen and Collagen-I and de novo phosphorylation of pSMAD2. LY2157299 inhibited HCC migration and cell growth independently of the expression levels of TGF-bRII. In contrast to LY2157299, D10 showed a reduction in pSMAD2 only after a short exposure. This study supports the use of LY2157299 in clinical trials, and presents new insights into TGF-b receptor cycling in cancer cells.
dc.format.extent15 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec639728
dc.identifier.issn1932-6203
dc.identifier.pmid23826206
dc.identifier.urihttps://hdl.handle.net/2445/97493
dc.language.isoeng
dc.publisherPublic Library of Science (PLoS)
dc.relation.isformatofReproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0067109
dc.relation.ispartofPLoS One, 2013, vol. 8, num. 6, p. e67109
dc.relation.urihttp://dx.doi.org/10.1371/journal.pone.0067109
dc.rightscc-by (c) Dituri, Francesco et al., 2013
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es
dc.sourceArticles publicats en revistes (Ciències Fisiològiques)
dc.subject.classificationAnticossos monoclonals
dc.subject.classificationFosforilació
dc.subject.classificationCàncer de fetge
dc.subject.classificationFactors de creixement
dc.subject.otherMonoclonal antibodies
dc.subject.otherPhosphorylation
dc.subject.otherLiver cancer
dc.subject.otherGrowth factors
dc.titleDifferential inhibition of the TGF-b signaling pathway in HCC cells using the small molecule inhibitor LY2157299 and the D10 monoclonal antibody against TGF-β receptor Type II
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

Fitxers

Paquet original

Mostrant 1 - 1 de 1
Miniatura
Nom:
639728.pdf
Mida:
16.26 MB
Format:
Adobe Portable Document Format
Descarregar

Col·leccions

Articles publicats en revistes (Ciències Fisiològiques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))