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2018-05

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/140447

Transcriptional network analysis in frontal cortex in Lewy body diseases with focus on dementia with Lewy bodies

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https://doi.org/10.1111/bpa.12511

Resum

The present study investigates global transcriptional changes in frontal cortex area 8 in incidental Lewy Body disease (iLBD), Parkinson disease (PD) and Dementia with Lewy bodies (DLB). We identified different co-expressed gene sets associated with disease stages, and gene ontology categories enriched in gene modules and differentially expressed genes including modules or gene clusters correlated to iLBD comprising upregulated dynein genes and taste receptors, and down-regulated innate inflammation. Focusing on DLB, we found modules with genes significantly enriched in functions related to RNA and DNA production, mitochondria and energy metabolism, purine metabolism, chaperone and protein folding system, and synapses and neurotransmission (particularly the GABAergic system). The expression of more than fifty selected genes was assessed with RT-qPCR. Our findings provide, for the first time, evidence of molecular cortical alterations in iLBD and involvement of several key metabolic pathways and gene hubs in DLB which may underlie cognitive impairment and dementia. Key words: Lewy body diseases, dementia with Lewy bodies, cerebral cortex, transcriptome, mitochondria, synapses, neurotransmission, GABA, purine metabolism, chaperones, dynein, axonema, taste receptors.

Matèries

Lòbul frontal, Metabolisme, Demència amb cossos de Lewy, Genètica, Malaltia de Parkinson

Matèries (anglès)

Frontal lobe, Metabolism, Lewy body dementia, Genetics, Parkinson's disease

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Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

SANTPERE BARÓ, Gabriel, GARCIA ESPARCIA, Paula, ANDRÉS BENITO, Pol, LORENTE-GALDOS, Belen, NAVARRO I CUARTIELLAS, Arcadi, FERRER, Isidro (ferrer abizanda). Transcriptional network analysis in frontal cortex in Lewy body diseases with focus on dementia with Lewy bodies. _Brain Pathology_. 2018. Vol. 28, núm. 3, pàgs. 315-333. [consulta: 14 de gener de 2026]. ISSN: 1015-6305. [Disponible a: https://hdl.handle.net/2445/140447]

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