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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/116287
Cardiovascular benefits of moderate exercise training in Marfan syndrome: Insights from an animal model.
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BACKGROUND: Marfan syndrome (MF) leads to aortic root dilatation and a predisposition to aortic dissection, mitral valve prolapse, and primary and secondary cardiomyopathy. Overall, regular physical exercise is recommended for a healthy lifestyle, but dynamic sports are strongly discouraged in MF patients. Nonetheless, evidence supporting this recommendation is lacking. Therefore, we studied the role of long-term dynamic exercise of moderate intensity on the MF cardiovascular phenotype. METHODS AND RESULTS: In a transgenic mouse model of MF (Fbn1C1039G/+), 4-month-old wild-type and MF mice were subjected to training on a treadmill for 5 months; sedentary littermates served as controls for each group. Aortic and cardiac remodeling was assessed by echocardiography and histology. The 4-month-old MF mice showed aortic root dilatation, elastic lamina rupture, and tunica media fibrosis, as well as cardiac hypertrophy, left ventricular fibrosis, and intramyocardial vessel remodeling. Over the 5-month experimental period, aortic root dilation rate was significantly greater in the sedentary MF group, compared with the wild-type group (∆mm, 0.27±0.07 versus 0.13±0.02, respectively). Exercise significantly blunted the aortic root dilation rate in MF mice compared with sedentary MF littermates (∆mm, 0.10±0.04 versus 0.27±0.07, respectively). However, these 2 groups were indistinguishable by aortic root stiffness, tunica media fibrosis, and elastic lamina ruptures. In MF mice, exercise also produced cardiac hypertrophy regression without changes in left ventricular fibrosis. CONCLUSIONS: Our results in a transgenic mouse model of MF indicate that moderate dynamic exercise mitigates the progression of the MF cardiovascular phenotype.
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MAS-STACHURSKA, Aleksandra, SIEGERT, Anna-maria elisa, BATLLE, Montserrat, GORBENKO DEL BLANCO, Darya, MEIRELLES, Thayna, RUBIES, Cira, BONORINO, Fabio, SERRA-PEINADO, Carla, BIJNENS, Bart, BAUDIN, Julio, SITGES CARREÑO, Marta, MONT GIRBAU, Lluís, GUASCH I CASANY, Eduard, EGEA GURI, Gustavo. Cardiovascular benefits of moderate exercise training in Marfan syndrome: Insights from an animal model.. _Journal Of The American Heart Association_. 2017. Vol. 6, núm. 9, pàgs. e006438. [consulta: 14 de gener de 2026]. ISSN: 2047-9980. [Disponible a: https://hdl.handle.net/2445/116287]