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2014-10-10

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/67989

Neuroprotective role of trans-resveratrol in a murine model of familial Alzheimer's disease 

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http://dx.doi.org/10.3233/JAD-140444

Abstract

The amyloid-β protein precursor/presenilin 1 (AβPP/PS1) mouse model of Alzheimer's disease (AD) has provided robust neuropathological hallmarks of familial AD-like pattern. AD is a neurodegenerative process that causes severe cognitive impairment; it is characterized by the accumulation of amyloid-β (Aβ) and hyperphosphorylated tau forms and by oxidative and inflammatory processes in brain. Currently, efforts are made to understand biochemical pathways because there is no effective therapy for AD. Resveratrol is a polyphenol that induces expression and activation of several neuroprotective pathways involving Sirtuin1 and AMPK. The objective of this work was to assess the effect of oral resveratrol administration on AβPP/PS1 mice. Long-term resveratrol treatment significantly prevented memory loss as measured by the object recognition test. Moreover, resveratrol reduced the amyloid burden and increased mitochondrial complex IV protein levels in mouse brain. These protective effects of resveratrol were mainly mediated by increased activation of Sirtuin 1 and AMPK pathways in mice. However, an increase has been observed in IL1β and TNF gene expression, indicating that resveratrol promoted changes in inflammatory processes, although no changes were detected in other key actors of the oxidative stress pathway. Taken together, our findings suggest that resveratrol is able to reduce the harmful process that occurs in AβPP/PS1 mouse hippocampus, preventing memory loss.

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Malaltia d'Alzheimer, Mitocondris, Malalties neurodegeneratives, Polifenols

Subject (English)

Alzheimer's disease, Mitochondria, Neurodegenerative Diseases, Polyphenols

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Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citation

PORQUET COSTA, David, et al. Neuroprotective role of trans-resveratrol in a murine model of familial Alzheimer's disease . Journal of Alzheimer's Disease. 2014. Vol. 42, num. 4, pags. 1209-1220. ISSN 1387-2877. [consulted: 14 of August of 2026]. Available at: https://hdl.handle.net/2445/67989

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