Association between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer’s disease

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dc.contributor.authorRodríguez-Fernández, Blanca
dc.contributor.authorSánchez-Benavides, Gonzalo
dc.contributor.authorGenius, Patricia
dc.contributor.authorMinguillón, Carolina
dc.contributor.authorFauria, Karine
dc.contributor.authorDe Vivo, Immaculata
dc.contributor.authorNavarro, Arcadi
dc.contributor.authorMolinuevo, Jose Luis
dc.contributor.authorGispert, Juan Domingo
dc.contributor.authorSala-Vila, Aleix
dc.contributor.authorVilor Tejedor, Natalia
dc.contributor.authorCrous Bou, Marta
dc.date.accessioned2024-10-14T12:40:17Z
dc.date.available2024-10-14T12:40:17Z
dc.date.issued2024-09-01
dc.date.updated2024-10-09T10:11:45Z
dc.description.abstractIntroduction: Leukocyte telomere length (LTL) is an objective biomarker of biological aging, and it is proposed to play a crucial role in Alzheimer's disease (AD) risk. We aimed at evaluating the cross-sectional association between LTL and cognitive performance in middle-aged cognitively unimpaired individuals at increased risk of AD. Methods: A total of 1520 participants from the ALFA cohort were included. Relative telomere length was measured in leukocytes through qPCR. LTL was residualized against age and sex, and associations with cognitive performance were assessed in short and long groups based on residualized LTL (rLTL). Interactions with sex and genetic risk of AD were tested. Results: Non-linear associations were found between LTL and episodic memory (EM). Better EM was associated with longer rLTL among women in the short rLTL group. Discussion: Results suggest a potential role of telomeres in the cognitive aging process with sex-specific patterns.
dc.format.extent11 p.
dc.format.mimetypeapplication/pdf
dc.identifier.issn0197-4580
dc.identifier.pmid38936230
dc.identifier.urihttps://hdl.handle.net/2445/215735
dc.language.isoeng
dc.publisherElsevier BV
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1016/j.neurobiolaging.2024.05.015
dc.relation.ispartofNeurobiology of Aging, 2024, vol. 141, p. 140-150
dc.relation.urihttps://doi.org/10.1016/j.neurobiolaging.2024.05.015
dc.rightscc by-nc-nd (c) Rodríguez-Fernánez, Blanca et al., 2024
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.sourceArticles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
dc.subject.classificationMalaltia d'Alzheimer
dc.subject.classificationTelòmer
dc.subject.otherAlzheimer's disease
dc.subject.otherTelomere
dc.titleAssociation between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer’s disease
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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