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695960.pdf (881 KB)

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2015-10-01

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cc-by (c) Vaquerizo, Beatriz et al., 2015
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/177231

Treatment of small vessel disease with the paclitaxel drug-eluting balloon: 6-month angiographic and 1-year clinical outcomes of the Spanish multicenter registry

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https://doi.org/10.1111/joic.12227

Resum

Background: small vessel disease (SMD) remains a major challenge because of the increased risk of restenosis. We sought to assess the efficacy and safety of a paclitaxel-eluting balloon (PEB) in patients with SMD. Methods and results: one-hundred and four patients with native coronary lesions in small vessels treated by using a PEB were included in this prospective multicenter registry. In each case, after regular balloon dilatation, a larger PEB was inflated for a minimum of 45-60 seconds. Patients were 65 ± 10 years old, 43% diabetic, and 58% presented acutely. Angiographic success was 93% (7% bailout BMS implantation due to coronary dissection). The rate of major adverse cardiac events (MACE) at 12 months was 4.8% (1.9% cardiac death, 1.0% MI, and 2.9% TLR). One definite stent thrombosis was reported at 6 months in a patient with bailout BMS implantation. At 7 months, late loss was 0.31 ± 0.2 mm. Bail-out BMS after DEB use, was an independent predictor of MACE, HR 18.74, 95%CI (2.58-135.84) and TLR, HR 30.99, 95%CI (2.79-344.07). Conclusion: the use of this PEB for the treatment of SMD provides excellent 1-year outcomes with only 4.8% MACE. The need for a bailout BMS was a strong predictor of MACE and TLR.

Matèries

Efectes secundaris dels medicaments, Malalties coronàries, Pròtesis de Stent, Ús terapèutic

Matèries (anglès)

Drug side effects, Coronary diseases, Stents (Surgery), Therapeutic use

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Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

VAQUERIZO, Beatriz, MIRANDA-GUARDIOLA, Faustino, FERNÁNDEZ, Eduardo, RUMOROSO, José ramón, GÓMEZ HOSPITAL, Josep antoni, BOSSA, Francisco, IÑIGUEZ ROMO, Andres, OATEGUI, Imanol, SERRA, Antonio. Treatment of small vessel disease with the paclitaxel drug-eluting balloon: 6-month angiographic and 1-year clinical outcomes of the Spanish multicenter registry. _Journal of Interventional Cardiology_. 2015. Vol. 28, núm. 5, pàgs. 430-438. [consulta: 6 de maig de 2026]. ISSN: 0896-4327. [Disponible a: https://hdl.handle.net/2445/177231]

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