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Article

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Accepted version

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2012-07-15

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/45643

Design and optimization of selfnanoemulsifying drug delivery systems for enhanced dissolution of gemfibrozil

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http://dx.doi.org/10.1016/j.ijpharm.2012.04.001

Abstract

Self-nanoemulsifying drug delivery systems of gemfibrozil were developed under Quality by Design approach for improvement of dissolution and oral absorption. Preliminary screening was performed to select proper components combination. Box-Behnken experimental design was employed as statistical tool to optimize the formulation variables, X1 (Cremophor® EL), X2 (Capmul® MCM-C8), and X3 (lemon essential oil). Systems were assessed for visual characteristics (emulsification efficacy), turbidity, droplet size, polydispersity index and drug release. Different pH media were also assayed for optimization. Following optimization, the values of formulation components (X1, X2, and X3) were 32.43%, 29.73% and 21.62%, respectively (16.22% of gemfibrozil). Transmission electron microscopy demonstrated spherical droplet morphology. SNEEDS release study was compared to commercial tablets. Optimized SNEDDS formulation of gemfibrozil showed a significant increase in dissolution rate compared to conventional tablets. Both formulations followed Weibull mathematical model release with a significant difference in td parameter in favor of the SNEDDS. Equally amodelistic parameters were calculated being the dissolution efficiency significantly higher for SNEDDS, confirming that the developed SNEDDS formulation was superior to commercial formulation with respect to in vitro dissolution profile. This paper provides an overview of the SNEDDS of the gemfibrozil as a promising alternative to improve oral absorption.

Subject

Sistemes d'administració de medicaments, Medicaments cardiovasculars, Nanoestructures, Agents tensioactius, Olis vegetals

Subject (English)

Drug delivery systems, Cardiovascular agents, Nanostructures, Surface active agents, Vegetable oils

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Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

Citation

SIERRA VILLAR, Ana María, et al. Design and optimization of selfnanoemulsifying drug delivery systems for enhanced dissolution of gemfibrozil. International Journal of Pharmaceutics. 2012. Vol. 431, num. 1-2, pags. 161-175. ISSN 0378-5173. [consulted: 16 of August of 2026]. Available at: https://hdl.handle.net/2445/45643

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