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2021-12-12

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cc-by (c) Pérez-González, Noelia et al., 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/183031

New Formulations Loading Caspofungin for Topical Therapy of Vulvovaginal Candidiasis

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Recurs relacionat

https://doi.org/10.3390/gels7040259

Resum

Vulvovaginal candidiasis (VVC) poses a significant problem worldwide affecting women from all strata of society. It is manifested as changes in vaginal discharge, irritation, itching and stinging sensation. Although most patients respond to topical treatment, there is still a need for increase the therapeutic arsenal due to resistances to anti-infective agents. The present study was designed to develop and characterize three hydrogels of chitosan (CTS), Poloxamer 407 (P407) and a combination of both containing 2% caspofungin (CSP) for the vaginal treatment of VVC. CTS was used by its mucoadhesive properties and P407 was used to exploit potential advantages related to increasing drug concentration in order to provide a local effect. The formulations were physically, mechanically and morphologically characterized. Drug release profile and ex vivo vaginal permeation studies were performed. Antifungal efficacy against different strains of Candida spp. was also evaluated. In addition, tolerance of formulations was studied by histological analysis. Results confirmed that CSP hydrogels could be proposed as promising candidates for the treatment of VVC

Matèries

Candidiasi, Malalties de l'aparell genital femení, Medicaments antifúngics

Matèries (anglès)

Candidiasis, Female reproductive system diseases, Antifungal agents

Citació

Col·leccions

Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
Articles publicats en revistes (Bioquímica i Fisiologia)

Citació

PÉREZ-GONZÁLEZ, Noelia, BOZAL DE FEBRER, Núria, CALPENA CAMPMANY, Ana cristina, NARDI RICART, Anna, RODRÍGUEZ LAGUNAS, María josé, MORALES-MOLINA, José a., SORIANO-RUIZ, José l., FERNÁNDEZ CAMPOS, Francisco, CLARES NAVEROS, Beatriz. New Formulations Loading Caspofungin for Topical Therapy of Vulvovaginal Candidiasis. _Gels_. 2021. Vol. 7, núm. 259. [consulta: 21 de gener de 2026]. ISSN: 2310-2861. [Disponible a: https://hdl.handle.net/2445/183031]

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