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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/116084
Voltammetric determination of antihypertensive drug hydrochlorothiazide using screen-printed electrodes modified with L- glutamic acid
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This work deals with the development of screen-printed carbon electrodes modified with L-glutamic acid via two different approaches: electropolymerization (SPCE/PGA) and aryl diazonium electrochemical grafting (SPCE/EGA). SPCE/PGA and SPCE/EGA were analytically compared in the determination of hydrochlorothiazide (HCTZ) by differential pulse voltammetry. Both electrochemical characterization and analytical performance indicate that SPCE/EGA is a much better sensor for HCTZ. The detection and quantification limits were at the level of micromol L-1 with a very good linearity in the studied concentration range. In addition, the proposed SPCE/EGA was successfully applied for the determination of HCTZ in an anti-hypertensive drug with high reproducibility and good trueness.
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GONZÁLEZ-VARGAS, Camilo, SERRANO I PLANA, Núria, ARIÑO BLASCO, Cristina, SALAZAR, Ricardo, ESTEBAN I CORTADA, Miquel, DÍAZ CRUZ, José manuel. Voltammetric determination of antihypertensive drug hydrochlorothiazide using screen-printed electrodes modified with L- glutamic acid. _Chemosensors_. 2017. Vol. 5, núm. 25, pàgs. 1-12. [consulta: 31 de gener de 2026]. ISSN: 2227-9040. [Disponible a: https://hdl.handle.net/2445/116084]