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fmed-08-699644.pdf (1.01 MB)

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2021-09-27

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cc by (c) Polke, Markus et al, 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/180935

Management of Acute Exacerbation of Idiopathic Pulmonary Fibrosis in Specialised and Non-specialised ILD Centres Around the World

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https://doi.org/10.3389/fmed.2021.699644

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Background: Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is a severe complication associated with a high mortality. However, evidence and guidance on management is sparse. The aim of this international survey was to assess differences in prevention, diagnostic and treatment strategies for AE-IPF in specialised and non-specialised ILD centres worldwide. Material and Methods: Pulmonologists working in specialised and non-specialised ILD centres were invited to participate in a survey designed by an international expert panel. Responses were evaluated in respect to the physicians' institutions. Results: Three hundred and two (65%) of the respondents worked in a specialised ILD centre, 134 (29%) in a non-specialised pulmonology centre. Similarities were frequent with regards to diagnostic methods including radiology and screening for infection, treatment with corticosteroids, use of high-flow oxygen and non-invasive ventilation in critical ill patients and palliative strategies. However, differences were significant in terms of the use of KL-6 and pathogen testing in urine, treatments with cyclosporine and recombinant thrombomodulin, extracorporeal membrane oxygenation in critical ill patients as well as antacid medication and anaesthesia measures as preventive methods. Conclusion: Despite the absence of recommendations, approaches to the prevention, diagnosis and treatment of AE-IPF are comparable in specialised and non-specialised ILD centres, yet certain differences in the managements of AE-IPF exist. Clinical trials and guidelines are needed to improve patient care and prognosis in AE-IPF.

Matèries

Fibrosi pulmonar, Terapèutica

Matèries (anglès)

Pulmonary fibrosis, Therapeutics

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

POLKE, Markus, KONDOH, Yasuhiro, WIJSENBEEK, Marlies, COTTIN, Vincent, WALSH, Simon l. f., COLLARD, Harold r., CHAUDHURI, Nazia, AVDEEV, Sergey, BEHR, Jürgen, CALLIGARO, Gregory, CORTE, Tamera j., FLAHERTY, Kevin, FUNKE CHAMBOUR, Manuela, KOLB, Martin, KRISAM, Johannes, MAHER, Toby m., MOLINA MOLINA, María, MORAIS, Antonio, MOOR, Catharina c., MORISSET, Julie, PEREIRA, Carlos, QUADRELLI, Silvia, SELMAN, Moises, TZOUVELEKIS, Argyrios, VALENZUELA, Claudia, VANCHERI, Carlo, VICENS ZYGMUNT, Vanesa, WÄLSCHER, Julia, WUYTS, Wim, BENDSTRUP, Elisabeth, KREUTER, Michael. Management of Acute Exacerbation of Idiopathic Pulmonary Fibrosis in Specialised and Non-specialised ILD Centres Around the World. _Frontiers in Medicine_. 2021. Vol. 8. [consulta: 23 de gener de 2026]. ISSN: 2296-858X. [Disponible a: https://hdl.handle.net/2445/180935]

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