Miniatura

Fitxers

649753.pdf (184.25 KB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2012-11-15

Llicència de publicació

cc-by (c) García Bermúdez, Mercedes et al., 2012
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/104024

Study of association of CD40-CD154 gene polymorphisms with disease susceptibility and cardiovascular risk in Spanish rheumatoid arthritis patients

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1371/journal.pone.0049214

Resum

Objective: rheumatoid arthritis (RA) is a chronic inflammatory disease associated with increased cardiovascular (CV) mortality. Since CD40-CD154 binding has direct consequences on inflammation process initiation, we aimed to replicate previous findings related to disease susceptibility in Spanish RA population. Furthermore, as the major complication in RA disease patients is the development of CV events due to accelerated atherosclerosis, and elevated levels of CD40L/CD154 are present in patients with acute myocardial infarction, we assessed the potential association of CD40 and CD154/CD40L gene variants with CV risk in Spanish RA patients. Methods: one thousand five hundred and seventy-five patients fulfilling the 1987 ACR classification criteria for RA and 1600 matched controls were genotyped for the CD40 rs1883832, rs4810485 and rs1535045 and CD154 rs3092952 and rs3092920 gene polymorphisms, using predesigned TaqMan single nucleotide polymorphism genotyping assays. Afterwards, we investigated the influence of CD40-CD154 gene variants in the development of CV events. Also, in a subgroup of 273 patients without history of CV events, we assessed the influence of these polymorphisms in the risk of subclinical atherosclerosis determined by carotid ultrasonography. Results: nominally significant differences in the allele frequencies for the rs1883832 CD40 gene polymorphism between RA patients and controls were found (p = 0.038). Although we did not observe a significant association of CD40-CD154 gene variants with the development of CV events, an ANCOVA model adjusted for sex, age at the time of the ultrasonography assessment, follow-up time, traditional CV risk factors and anti-cyclic citrullinated peptide antibodies disclosed a significant association (p = 0.0047) between CD40 rs1535045 polymorphism and carotid intima media thickness, a surrogate marker of atherosclerosis. Conclusion: data from our pilot study indicate a potential association of rs1883832 CD40 gene polymorphism with susceptibility to RA. Also, the CD40 rs1535045 gene variant may influence development of subclinical atherosclerosis in RA patients.

Matèries

Artritis reumatoide, Reumatisme, Polimorfisme genètic, Malalties cardiovasculars, Aterosclerosi, Espanya

Matèries (anglès)

Rheumatoid arthritis, Rheumatism, Genetic polymorphisms, Cardiovascular diseases, Atherosclerosis, Spain

Citació

Col·leccions

Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

GARCÍA-BERMÚDEZ, Mercedes, GONZÁLEZ JUANATEY, Carlos, LÓPEZ MEJÍAS, Raquel, TERUEL, María, CORRALES, Alfonso, MIRANDA-FILLOY, José a., CASTAÑEDA, Santos, BALSA, Alejandro, FERNÁNDEZ-GUTIÉRREZ, Benjamín, GONZÁLEZ ÁLVARO, Isidoro, GÓMEZ VAQUERO, Carmen, BLANCO, Ricardo, LLORCA DÍAZ, Javier, MARTÍN, Javier, GONZÁLEZ-GAY, Miguel a.. Study of association of CD40-CD154 gene polymorphisms with disease susceptibility and cardiovascular risk in Spanish rheumatoid arthritis patients. _PLoS One_. 2012. Vol. 7, núm. 11, pàgs. e49214. [consulta: 21 de gener de 2026]. ISSN: 1932-6203. [Disponible a: https://hdl.handle.net/2445/104024]

Exportar metadades

JSON - METS

Compartir registre