Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/171732
New Biomarkers in Acute Tubulointerstitial Nephritis: A Novel Approach to a Classic Condition
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Acute tubulointerstitial nephritis (ATIN) is an immunomediated cause of acute kidney injury. The prevalence of ATIN among the causes of acute kidney injury (AKI) is not negligible, especially those cases related to certain drugs. To date, there is a lack of reliable non-invasive diagnostic and follow-up markers. The gold standard for diagnosis is kidney biopsy, which shows a pattern of tubulointerstitial leukocyte infiltrate. The urinalysis findings can aid in the diagnosis but are no longer considered sensitive or specific. Atthe present time, there is a rising attentiveness tofinding trustworthy biomarkers of the disease, with special focus in urinary cytokines and chemokines that may reflect kidney local inflammation. Cell-based tests are of notable interest to identify the exact drug involved in hypersensitivity reactions to drugs, manifesting as ATIN. Certain single-nucleotide polymorphisms in HLA or cytokine genes may confer susceptibility to the disease according to pathophysiological basis. In this review, we aim to critically examine and summarize the available evidence on this topic.
Matèries (anglès)
Citació
Citació
MARTINEZ VALENZUELA, Laura, DRAIBE, Juliana, FULLADOSA, Xavier, TORRAS AMBRÒS, Joan. New Biomarkers in Acute Tubulointerstitial Nephritis: A Novel Approach to a Classic Condition. _International Journal of Molecular Sciences_. 2020. Vol. 21, núm. 13, pàgs. 4690. [consulta: 10 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/171732]