Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/161866
Addition of hyaluronic acid improves tlerance to 7% hypertonic saline solution in bronchiectasis patients.
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Background: The excessive retention of sputum in the airways, leading to pulmonary infections, is a common consequence of bronchiectasis. Although inhalation of 7% hypertonic saline (HS) has proven an effective method to help remove the mucus, many patients are intolerant of this treatment. The addition of 0.1% hyaluronic acid to HS (HS+HA) could increase tolerance to HS in these patients. The main objective of this study was to evaluate the tolerability of HS+HA in bronchiectasis patients who are intolerant to HS. Methods: This prospective, observational, open-label study analysed the outcomes of two groups of bronchiectasis patients previously scheduled to start HS therapy. Patients were assessed for tolerance to HS by a questionnaire, spirometry and clinical evaluation. Patients who were intolerant were evaluated for tolerance to HS+HA approximately one week later. All patients were evaluated for their tolerance to HS or HS+HA 4 weeks after the start of their treatment. Patients were also assessed with quality-of-life and adherence questionnaires, and all adverse events were registered. Results: A total of 137 bronchiectasis patients were enrolled in the study (age = 63.0 ± 14.7 years; 63.5% women). Of these, 92 patients (67.1%) were tolerant and 45 patients (32.9%) were intolerant to HS. Of the 45 patients intolerant to HS, 31 patients (68.9%) were tolerant and 14 patients (31.1%) intolerant to HS+HA. Of these 31 tolerant patients, 26 (83.9%) could complete the 4-week treatment with HS+HA. Conclusions: Two-thirds of bronchiectasis patients that presented intolerance to inhaled HS alone are tolerant to inhaled HS+HA, suggesting that HA improves tolerance to HS therapy.
Matèries (anglès)
Citació
Citació
MÁIZ, Luis, GIRÓN, Rosa maría, PRATS, Eva, CLEMENTE, Marta g., POLVERINO, Eva, CAÑO, Silvia, CORDOVILLA, Rosa, DORCA I SARGATAL, Jordi, PEÑALVER, Carlos, BARANDA, Félix, MARTÍNEZ GARCÍA, Miguel ángel. Addition of hyaluronic acid improves tlerance to 7% hypertonic saline solution in bronchiectasis patients.. _Therapeutic Advances In Respiratory Disease_. 2018. Vol. 12, núm. 1-10. [consulta: 21 de gener de 2026]. ISSN: 1753-4658. [Disponible a: https://hdl.handle.net/2445/161866]