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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/189013
Exonucleases: degrading DNA to deal with genome damage, cell death, inflammation and cancer
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Although DNA degradation might seem an unwanted event, it is essential in many cellular processes that are key to maintaining genomic stability and cell and organism homeostasis. The capacity to cut out nucleotides one at a time from the end of a DNA chain is present in enzymes called exonucleases. Exonuclease activity might come from enzymes with multiple other functions or specialized enzymes only dedicated to this function. Exonucleases are involved in central pathways of cell biology such as DNA replication, repair, and death, as well as tuning the immune response. Of note, malfunctioning of these enzymes is associated with immune disorders and cancer. In this review, we will dissect the impact of DNA degradation on the DNA damage response and its links with inflammation and cancer.
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MANILS PACHECO, Joan, MARRUECOS, Laura, SOLER PRAT, Concepció. Exonucleases: degrading DNA to deal with genome damage, cell death, inflammation and cancer. _Cells_. 2022. Vol. 11, núm. 14. [consulta: 26 de febrer de 2026]. ISSN: 2073-4409. [Disponible a: https://hdl.handle.net/2445/189013]