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RNU6-1 in circulating exosomes different.pdf (604.71 KB)

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2020-01-31

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cc-by-nc (c) Puigdelloses Vallcorba, Montserrat et al., 2020
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/222858

RNU6-1 in circulating exosomes differentiates GBM from non-neoplastic brain lesions and PCNSL but not from brain metastases

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https://doi.org/10.1093/noajnl/vdaa010

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Background. Glioblastoma (GBM) is the most common malignant primary brain tumor in adults. Circulating biomarkers may assist in the processes of differential diagnosis and response assessment. GBM cells release extracellular vesicles containing a subset of proteins and nucleic acids. We previously demonstrated that exosomes isolated from the serum of GBM patients had an increased expression of RNU6-1 compared to healthy subjects. In this exploratory study, we investigated the role of this small noncoding RNA as a diagnostic biomarker for GBM versus other brain lesions with some potential radiological similarities. Methods. We analyzed the expression of RNU6-1 in circulating exosomes of GBM patients (n = 18), healthy controls (n = 30), and patients with subacute stroke (n = 30), acute/subacute hemorrhage (n = 30), acute demyelinatinglesions (n = 18), brain metastases (n = 21), and primary central nervous system lymphoma (PCNSL; n = 12) using digital droplet PCR. Results. Expression of RNU6-1 was significantly higher in GBM patients than in healthy controls (P = .002).RNU6-1 levels were also significantly higher in exosomes from GBM patients than from patients with nonneoplastic lesions (stroke [P = .05], hemorrhage [P = .01], demyelinating lesions [P = .019]) and PCNSL (P = .004).In contrast, no significant differences were found between patients with GBM and brain metastases (P = .573).Receiver operator characteristic curve analyses supported the role of this biomarker in differentiating GBM from

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Tumors cerebrals, Metàstasi, Marcadors tumorals

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Brain tumors, Metastasis, Tumor markers

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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PUIGDELLOSES VALLCORBA, Montserrat, GONZÁLEZ HUARRIZ, Marisol, GARCÍA MOURE, Marc, MARTÍNEZ VÉLEZ, Naiara, ESPARRAGOSA VÁZQUEZ, Inés, BRUNA, Jordi, ZANDIO, Beatriz, AGIRRE, Amaia, MARIGIL, Miguel, PETRIRENA, Gregorio, NÚÑEZ CÓRDOBA, Jorge m., TEJADA SOLÍS, Sonia, DÍEZ VALLE, Ricardo, GÁLLEGO CULLERÉ, Jaime, MARTÍNEZ VILA, Eduardo, PATIÑO GARCÍA, Ana, ALONSO, Marta m., GÁLLEGO PÉREZ LARRAYA, Jaime. RNU6-1 in circulating exosomes differentiates GBM from non-neoplastic brain lesions and PCNSL but not from brain metastases. _Neuro-Oncology Advances_. 2020. Vol. 2, núm. 1. [consulta: 14 de gener de 2026]. ISSN: 2632-2498. [Disponible a: https://hdl.handle.net/2445/222858]

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