Characteristics of Colonoscopy- and Fecal Immunochemical Test-Based Screen-Detected Premalignant Neoplastic Lesions: Results From the COLONPREV Study

Abstract

Evidence from several studies have shown that colorectal cancer (CRC) screening is effective and cost-effective in average-risk individuals. The most common screening strategies are fecal immunochemical test (FIT) and colonoscopy. Whereas the former is predominantly implemented in Europe and Australia, the latter is the dominant screening modality in the US. . We have recently published the long-term results of COLONPREV study, the first randomized controlled trial comparing colonoscopy and FIT head-tohead, demonstrating that individuals invited to FIT were more likely to participate in screening than those invited to colonoscopy. More importantly, FIT-based screening program appeared not to be inferior to one based on primary colonoscopy in terms of CRC-related mortality and CRC incidence.