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2021-07-26

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cc-by (c) Vaqué Alcázar, Lídia et al., 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/195236

tDCS-Induced Memory Reconsolidation Effects and Its Associations With Structural and Functional MRI Substrates in Subjective Cognitive Decline

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https://doi.org/10.3389/fnagi.2021.695232

Resum

Previous evidence suggests that transcranial direct current stimulation (tDCS) to the left dorsolateral prefrontal cortex (l-DLPFC) can enhance episodic memory in subjects with subjective cognitive decline (SCD), known to be at risk of dementia. Our main goal was to replicate such findings in an independent sample and elucidate if baseline magnetic resonance imaging (MRI) characteristics predicted putative memory improvement. Thirty-eight participants with SCD (aged: 60-65 years) were randomly assigned to receive active (N = 19) or sham (N = 19) tDCS in a double-blind design. They underwent a verbal learning task with 15 words (DAY-1), and 24 h later (DAY-2) stimulation was applied for 15 min at 1.5 mA targeting the l-DLPFC after offering a contextual reminder. Delayed recall and recognition were measured 1 day after the stimulation session (DAY3), and at 1-month follow-up (DAY-30). Before the experimental session, structural and functional MRI were acquired. We identified a group∗ time interaction in recognition memory, being the active tDCS group able to maintain stable memory performance between DAY-3 and DAY-30. MRI results revealed that individuals with superior tDCSinduced effects on memory reconsolidation exhibited higher left temporal lobe thickness and greater intrinsic FC within the default-mode network. Present findings confirm that tDCS, through the modulation of memory reconsolidation, is capable of enhancing performance in people with self-perceived cognitive complaints. Results suggest that SCD subjects with more preserved structural and functional integrity might benefit from these interventions, promoting maintenance of cognitive function in a population at risk to develop dementia.

Matèries

Memòria, Trastorns de la memòria, Trastorns de la cognició, Imatges per ressonància magnètica, Estimulació del cervell

Matèries (anglès)

Memory, Memory disorders, Cognition disorders, Magnetic resonance imaging, Brain stimulation

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Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

VAQUÉ ALCÁZAR, Lídia, MULET PONS, Lídia, ABELLANEDA PÉREZ, Kilian, SOLÉ PADULLÉS, Cristina, CABELLO TOSCANO, María del rocío, MACIÀ BROS, Dídac, SALA LLONCH, Roser, BARGALLÓ ALABART, Núria​, SOLANA SÁNCHEZ, Javier, CATTANEO, Gabriele, TORMOS, José maría, PASCUAL LEONE, Álvaro, BARTRÉS FAZ, David. tDCS-Induced Memory Reconsolidation Effects and Its Associations With Structural and Functional MRI Substrates in Subjective Cognitive Decline. _Frontiers in Aging Neuroscience_. 2021. Vol. 13, núm. 695232. [consulta: 10 de gener de 2026]. ISSN: 1663-4365. [Disponible a: https://hdl.handle.net/2445/195236]

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