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2014-12-24

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cc-by (c) Henríquez-Hernández, Luis Alberto et al., 2014
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/118992

Single nucleotide polymorphisms in DNA repair genes as risk factors associated to prostate cancer progression

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https://doi.org/10.1186/s12881-014-0143-0

Abstract

Background: besides serum levels of PSA, there is a lack of prostate cancer specific biomarkers. It is need to develop new biological markers associated with the tumor behavior which would be valuable to better individualize treatment. The aim of this study was to elucidate the relationship between single nucleotide polymorphisms (SNPs) in genes involved in DNA repair and prostate cancer progression. Methods: a total of 494 prostate cancer patients from a Spanish multicenter study were genotyped for 10 SNPs in XRCC1, ERCC2, ERCC1, LIG4, ATM and TP53 genes. The SNP genotyping was made in a Biotrove OpenArray® NT Cycler. Clinical tumor stage, diagnostic PSA serum levels, and Gleason score at diagnosis were obtained for all participants. Genotypic and allelic frequencies were determined using the web-based environment SNPator. Results: SNPs rs11615 (ERCC1) and rs17503908 (ATM) appeared as risk factors for prostate cancer aggressiveness. Patients wild homozygous for these SNPs (AA and TT, respectively) were at higher risk for developing cT2b - cT4 (OR = 2.21 (confidence interval (CI) 95% 1.47 - 3.31), p < 0.001) and Gleason scores ≥ 7 (OR = 2.22 (CI 95% 1.38 - 3.57), p < 0.001), respectively. Moreover, those patients wild homozygous for both SNPs had the greatest risk of presenting D'Amico high-risk tumors (OR = 2.57 (CI 95% 1.28 - 5.16)).Conclusions: genetic variants at DNA repair genes are associated with prostate cancer progression, and would be taken into account when assessing the malignancy of prostate cancer.

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Polimorfisme genètic, Reparació de l'ADN, Càncer de pròstata, Marcadors tumorals, Factors de risc en les malalties, Espanya

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Genetic polymorphisms, DNA repair, Prostate cancer, Tumor markers, Risk factors in diseases, Spain

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Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citation

HENRÍQUEZ-HERNÁNDEZ, Luis Alberto, et al. Single nucleotide polymorphisms in DNA repair genes as risk factors associated to prostate cancer progression. BMC Medical Genetics. 2014. Vol. 15, num. 143. ISSN 1471-2350. [consulted: 10 of June of 2026]. Available at: https://hdl.handle.net/2445/118992

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