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2011-01-01

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/52204

Effectiveness of pharmacist care in the improvement of adherence to antidepressants: a systematic review and meta-analysis

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Recurs relacionat

http://dx.doi.org/10.1345/aph.1P429

Resum

BACKGROUND: Pharmacists can play a decisive role in the management of ambulatory patients with depression who have poor adherence to antidepressant drugs. OBJECTIVE: To systematically evaluate the effectiveness of pharmacist care in improving adherence of depressed outpatients to antidepressants. METHODS: A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted. RCTs were identified through electronic databases (MEDLINE, Cochrane Central Register of Controlled Trials, Institute for Scientific Information Web of Knowledge, and Spanish National Research Council) from inception to April 2010, reference lists were checked, and experts were consulted. RCTs that evaluated the impact of pharmacist interventions on improving adherence to antidepressants in depressed patients in an outpatient setting (community pharmacy or pharmacy service) were included. Methodologic quality was assessed and methodologic details and outcomes were extracted in duplicate. RESULTS: Six RCTs were identified. A total of 887 patients with an established diagnosis of depression who were initiating or maintaining pharmacologic treatment with antidepressant drugs and who received pharmacist care (459 patients) or usual care (428 patients) were included in the review. The most commonly reported interventions were patient education and monitoring, monitoring and management of toxicity and adverse effects, adherence promotion, provision of written or visual information, and recommendation or implementation of changes or adjustments in medication. Overall, no statistical heterogeneity or publication bias was detected. The pooled odds ratio, using a random effects model, was 1.64 (95% CI 1.24 to 2.17). Subgroup analysis showed no statistically significant differences in results by type of pharmacist involved, adherence measure, diagnostic tool, or analysis strategy. CONCLUSIONS: These results suggest that pharmacist intervention is effective in the improvement of patient adherence to antidepressants. However, data are still limited and we would recommend more research in this area, specifically outside of the US.

Matèries

Depressió psíquica, Serveis farmacèutics, Cooperació dels malalts, Antidepressius, Atenció primària, Metaanàlisi

Matèries (anglès)

Mental depression, Pharmaceutical services, Patient compliance, Antidepressants, Primary health care, Meta-analysis

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Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

Citació

RUBIO VALERA, Maria, SERRANO BLANCO, Antoni, MAGDALENA BELÍO, Jesús, FERNÁNDEZ SÁNCHEZ, Ana, GARCÍA CAMPAYO, Javier, MARCH PUJOL, Marian, LÓPEZ DEL HOYO, Yolanda. Effectiveness of pharmacist care in the improvement of adherence to antidepressants: a systematic review and meta-analysis. _Annals of Pharmacotherapy_. 2011. Vol. 45, núm. 1, pàgs. 39-48. [consulta: 8 de gener de 2026]. ISSN: 1060-0280. [Disponible a: https://hdl.handle.net/2445/52204]

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