Amb motiu del tancament d'estiu, la validació de documents es reprendrà a partir del 28 d'agost de 2026. Disculpeu les molèsties.
Con motivo del cierre de verano, la validación de documentos se reanudará a partir del 28 de agosto de 2026. Disculpad las molestias
Due to the summer closure, document validation will resume starting August 28, 2026. We apologize for any inconvenience.

Fitxers

219699.pdf (43.12 KB)

Tipus de document

Altres

Versió

Versió publicada

Data de publicació

2019-09-09

Tots els drets reservats

Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/230677

Impaired expression of ecto-nucleotidases in human endometrial pathologies

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

Resum

The levels of extracellular ATP and its derivatives such as adenosine are impaired in the tissue microenvironment during tissue stress conditions such as hypoxia, infection, metabolic stress, tumor transformation and inflammation. Ecto-nucleotidases are the main regulators of extracellular ATP and adenosine levels. The aim of the present work is to upgrade our understanding of the role and location of ecto-nucleotidases in the context of two endometrial pathologies: cancer and endometriosis, as well as to investigate new diagnostic and treatment modalities based on the inhibition of ecto-nucleotidases' activities. We have analyzed by means of immunolabeling and in situ enzyme histochemistry human endometrial samples from: 1) endometrial tumors, and, 2) eutopic endometria as well as ectòpic endometriotic lesions from women with endometriosis. We have also studied endometrial cell cultures to evaluate the consequences of the overexpression of ecto-nucleotidases in their proliferative and invasive phenotypes. Ecto-nucleotidases showed impaired expression in pathological conditions when compared with non-pathological endometria. This altered pattern includes changes in expression levels and changes in protein localization, mainly a switch between epithelium and stroma. Overexpression of ecto-nucleotidases in endometrial cell cultures lead to changes in the proliferation and invasion rates. Impaired ecto-nucleotidases activities in endometrium might contribute to the pathogenesis and maintenance of endometrial pathologies with an inflammatory component such as cancer and endometriosis.

Matèries

Nucleòtids, Endometriosi

Matèries (anglès)

Nucleotides, Endometriosis

Citació

Col·leccions

Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

MARTÍN SATUÉ, Mireia, et al. Impaired expression of ecto-nucleotidases in human endometrial pathologies. Histology and Histopathology. 2019. Vol. 34, num. S1, pags. S63-S63. ISSN 0213-3911. [consulted: 9 of August of 2026]. Available at: https://hdl.handle.net/2445/230677

Exportar metadades

JSON - METS

Compartir registre