Document type
ArticleVersion
Published versionPublication date
Publication license
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/124283
Accelerated oxygen-induced retinopathy is a reliable model of ischemia-induced retinal neovascularization
Journal Title
Director/Tutor
Journal ISSN
Volume Title
Related resource
Abstract
Retinal ischemia and pathological angiogenesis cause severe impairment of sight. Oxygen-induced retinopathy (OIR) in young mice is widely used as a model to investigate the underlying pathological mechanisms and develop therapeutic interventions. We compared directly the conventional OIR model (exposure to 75% O-2 from postnatal day (P) 7 to P12) with an alternative, accelerated version (85% O-2 from P8 to P11). We found that accelerated OIR induces similar pre-retinal neovascularization but greater retinal vascular regression that recovers more rapidly. The extent of retinal gliosis is similar but neuroretinal function, as measured by electroretinography, is better maintained in the accelerated model. We found no systemic or maternal morbidity in either model. Accelerated OIR offers a safe, reliable and more rapid alternative model in which pre-retinal neovascularization is similar but retinal vascular regression is greater.
Subject
Subject (English)
Citation
Citation
VILLACAMPA, Pilar, et al. Accelerated oxygen-induced retinopathy is a reliable model of ischemia-induced retinal neovascularization. PLoS One. 2017. Vol. 12, num. 6. [consulted: 9 of August of 2026]. Available at: https://hdl.handle.net/2445/124283